Genetic Association Between Polycystic Ovary Syndrome and the APOA5 rs662799 and PLIN1 rs894160 Metabolic Variants in the Western Saudi Population: A Case-Control Study

January 2024 in “ Biomarker Insights ”

Sherin Bakhashab, Asma A. Batarfi, Mahinar M Alhartani, Rola Turki, Wessam Mady

TLDR Certain genetic variants may increase the risk of developing PCOS.

This case-control study investigated the genetic association between polycystic ovary syndrome (PCOS) and the metabolic variants APOA5 rs662799 and PLIN1 rs894160 in the Western Saudi population. The study identified novel alleles and genotypes that contribute to the genetic risk of PCOS in this population, providing new insights into the genetic factors influencing the development of PCOS. The findings suggest that these specific genetic variants may play a role in the susceptibility to PCOS, highlighting the importance of genetic screening in understanding and potentially managing the condition.

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MC4R Variants rs12970134 and rs17782313 Are Associated with Obese Polycystic Ovary Syndrome Patients in the Western Region of Saudi Arabia

research MC4R Variants rs12970134 and rs17782313 Are Associated with Obese Polycystic Ovary Syndrome Patients in the Western Region of Saudi Arabia

12 citations , August 2019 in “BMC Medical Genetics”

Certain MC4R gene variants are linked to higher BMI in obese women with PCOS but do not cause PCOS.

research Serum Lipid Profile and Insulin Resistance in Women with Polycystic Ovary Syndrome

5 citations , June 2018 in “Journal of Diabetes, Metabolic Disorders & Control”

Women with PCOS may have higher bad cholesterol and are at risk for blood sugar issues; lifestyle changes are recommended.

research Comprehensive Overview of Polycystic Ovary Syndrome

883 citations , August 2016 in “Nature Reviews Disease Primers”

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

research Polycystic Ovary Syndrome: Etiology, Pathogenesis, and Diagnosis

991 citations , January 2011 in “Nature Reviews Endocrinology”

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

Polycystic Ovary Syndrome: A Complex Condition with Psychological, Reproductive, and Metabolic Manifestations That Impacts Health Across the Lifespan

research Polycystic Ovary Syndrome: A Complex Condition with Psychological, Reproductive, and Metabolic Manifestations That Impacts Health Across the Lifespan

926 citations , June 2010 in “BMC Medicine”

Polycystic ovary syndrome is a complex condition that affects women's mental, reproductive, and metabolic health throughout their lives.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.