Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that increasing the proportion of ethanol in minoxidil formulations improved skin penetration in both in vitro and in vivo tests on mice.

This study found that Transcutol P significantly enhanced the skin penetration of Finasteride in vitro, while cationic and anionic surfactants did not show such effects.

This review highlights the promising potential of microemulsions and nanoemulsions in (trans)dermal drug delivery, noting a gap in understanding their distinct mechanisms and composition-related effects on skin permeability, while emphasizing the limited clarity on mesostructures and cosolvent impacts.

This study assessed minoxidil solubility in propylene glycol and water mixtures, comparing cosolvency models and examining thermodynamic properties, without reporting new clinical results.

This study found that incorporating 0.5% TPGS into topical minoxidil solutions enhanced hair growth in mice, although increasing TPGS to 2% decreased effectiveness.

This study found that an optimized microemulsion for minoxidil with high solubility, permeation flux, and skin deposition can be achieved with specific low and high levels of certain surfactants and co-solvents.

The study found that cyproterone acetate could be released over 15 days using coconut oil mixed with certain wax inhibitors, though further safety studies are needed.

This study found that minoxidil exhibits preferential solvation by water in both water-rich and ethanol-rich solvent mixtures.

This review explores the formulation, characterization, and applications of microemulsions, highlighting their potential for enhanced cutaneous drug delivery by improving bioavailability and enabling sustained release of both hydrophilic and hydrophobic drugs.

This study investigated the physicochemical properties of polystyrene-b-poly(acrylic acid) nanovesicles coated with modified chitosans, finding that they can effectively control surface charge and potentially serve as drug delivery carriers with a 50.7% encapsulation efficiency for minoxidil.

This thesis explored how stratum corneum barrier disruption and pH-sensitive nanoparticles influence drug penetration and release in skin models, highlighting potential applications for treating atopic dermatitis.

This study focused on developing a nanoemulsion-based gel for delivering minoxidil, aiming to enhance its contact time with the scalp and potentially improve skin absorption compared to conventional topical solutions.

This study found that anisotropic osmolyte solutions may improve hair follicle turnover and condition in both in vitro and in silico models, as well as in human volunteers with hair disorders.

This review describes deep eutectic solvents as a green alternative to toxic solvents in extracting bioactive compounds, highlighting their sustainability, production from natural ingredients, and beneficial properties for pharmaceutical applications.

This article reviews the cutaneous reactions and characteristic skin changes associated with chemotherapy, radiation therapy, and new targeted cancer treatments, reporting no new clinical results.

This study investigated the solubility of minoxidil in various solvent mixtures and applied multiple models to understand solute-solvent interactions and energy dynamics.

This paper reviews the properties, characteristics, and applications of deep eutectic solvents as environmentally friendly alternatives for extracting bioactive compounds from natural sources in the pharmaceutical industry.

This study found that minoxidil penetration through the skin increased with higher ethanol content and occlusion, with the highest penetration observed at 90% ethanol.

This review explores the use of skin penetration enhancers like Transcutol® in various formulation systems, discussing their mechanisms and effectiveness in improving transdermal drug delivery without breaching the skin.

This study found that nano-sized minoxidil formulations significantly increased skin penetration and follicular drug delivery for alopecia areata treatment, compared to conventional ethanol-based solutions, and demonstrated effective controlled release over six hours.

This research investigated aqueous alginate-based hydrogels for delivering minoxidil and reported that using hydroxypropyl-β-cyclodextrin (HP-β-CD) with molar substitution 0.65 significantly enhanced minoxidil's solubility and skin permeability without damaging the epidermis, suggesting potential as an alternative to commercial minoxidil solutions.

This study found that freeze-dried finasteride nanoparticles improved the stability, solubility, and in vitro dissolution of the drug, indicating potential benefits for poorly water-soluble drugs.

This study found that the desolvation of finasteride hydrate solvates is highly dependent on the physical environment, complicating investigations but providing insight through complementary analysis techniques.

This study evaluated a new nanogel formulation containing Ciclopirox Olamine for treating cutaneous candidiasis, finding that the optimized version offered improved skin penetration, sustained drug release, and effective antifungal action against Candida albicans compared to conventional treatment.

This review discusses therapeutic deep eutectic solvents as promising "green" solutions for enhancing drug solubility and delivery through the skin, reporting no new clinical results and highlighting future research directions.

This review describes minoxidil's hair regrowth mechanism and discusses dermatological applications, but reports no new clinical results, emphasizing the need for regular use and addressing allergic reactions.

This review article provides an updated overview of the pharmacology, mechanism of action, clinical efficacy, and adverse events associated with topical minoxidil, a widely used treatment for androgenetic alopecia and other hair loss conditions, while noting that its exact mechanism is still not fully understood.

This review discusses the potential use of liposomal formulations to enhance the effectiveness of cosmeceutical delivery through the skin barrier, with no new clinical results reported.

This review discusses niosomes' increasing popularity in dermatology for topical drug delivery due to their ability to enhance drug penetration, provide sustained release, and carry various drugs, while reporting no new clinical findings.

This study found that ethanol-containing formulations significantly increased minoxidil retention in the stratum corneum and appendages initially, while a propylene glycol-rich formulation enhanced deeper skin penetration over time.