Cyproterone Acetate Sustained-Release Injection Using Mixed Coconut Oil/Solvent as Vehicle
June 2021
in “
SWU eJournals System (Srinakharinwirot University)
”
TLDR Mixed coconut oil/solvent is suitable for cyproterone acetate injections, but more safety checks are needed.
The study focused on developing a sustained-release injection of cyproterone acetate (CPA) using coconut oil (CO) mixed with solvents as a vehicle. The researchers prepared CPA-loaded injectable CO vehicles with wax inhibitors like N-methyl pyrrolidone (NMP), benzyl benzoate (BB), and peppermint oil (PO). The addition of these inhibitors did not significantly alter the physicochemical properties of CO but effectively reduced the wax appearance temperature and pour point. The CPA release was sustained for 15 days through Fickian diffusion, with NMP enhancing the release rate compared to plain CO, while BB and PO, due to their hydrophobic nature, slowed the release. The study concluded that the mixed CO/solvent vehicle is suitable for CPA injections, but further safety evaluations are necessary.
