Influences of Skin Barrier, a Nanoparticle-Based Vehicle and Solvents on Cutaneous Drug Delivery

    January 2020 in “ Refubium (Universitätsbibliothek der Freien Universität Berlin) ”
    Pin Dong
    TLDR Disrupting the skin barrier and using specific nanoparticles and solvents can improve drug delivery through the skin.
    The study explored the challenges of delivering drugs through the skin's stratum corneum (SC) barrier, focusing on nanoparticle (NP)-based systems and solvents as penetration enhancers. It was found that both tape stripping (TS) and cyanoacrylate stripping (CS) could effectively remove the SC, with CS also removing deeper skin layers and hair follicles. The study demonstrated that a pH-sensitive Eudragit® L100 NP could enhance drug delivery in barrier-disrupted skin, simulating conditions like atopic dermatitis (AD), and potentially reduce drug side effects. Solvents like ethanol and PBS were examined for their effects on drug penetration, revealing that while ethanol alone was less effective, a cosolvent of ethanol-PBS improved drug delivery into viable skin layers. The research provided insights into the SC's role as a barrier and reservoir, the potential of NPs for targeted drug release, and the influence of solvents on drug localization within the skin.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 24 results

      community PP405 is NOT gray market jxl069

      in Technology  24 upvotes 2 weeks ago
      PP405 is a safer alternative to JXL069 for hair loss treatment because it penetrates the skin effectively and degrades in the blood, avoiding systemic toxicity. JXL069, when forced into the body, can cause dangerous side effects like lactic acidosis due to its inability to degrade safely.

      community Why do I see so many people here recommend microneedling?

      in Microneedling  107 upvotes 2 years ago
      The efficacy of microneedling for hair regrowth as either a stand-alone therapy or adjunct to Minoxidil, and whether Tretinoin is a safer and more effective option. Replies include personal accounts from users who have had success with microneedling in combination with minoxidil and peptide serums, as well as considerations of technique, depth, and potential scarring.

      community Dr Kyle Gillett on topical Dutasteride

      in Finasteride/Dutasteride  56 upvotes 3 years ago
      The potential effectiveness of topical dutasteride, as well as other hair loss treatments such as finasteride, RU58841, minoxidil, and various vitamins. Experiences from users who have used these treatments were shared.

    Related Research

    1 / 1 results