Influences of Skin Barrier, a Nanoparticle-Based Vehicle and Solvents on Cutaneous Drug Delivery

    January 2020 in “ Refubium (Universitätsbibliothek der Freien Universität Berlin) ”
    Pin Dong
    TLDR Disrupting the skin barrier and using specific nanoparticles and solvents can improve drug delivery through the skin.
    The study explored the challenges of delivering drugs through the skin's stratum corneum (SC) barrier, focusing on nanoparticle (NP)-based systems and solvents as penetration enhancers. It was found that both tape stripping (TS) and cyanoacrylate stripping (CS) could effectively remove the SC, with CS also removing deeper skin layers and hair follicles. The study demonstrated that a pH-sensitive Eudragit® L100 NP could enhance drug delivery in barrier-disrupted skin, simulating conditions like atopic dermatitis (AD), and potentially reduce drug side effects. Solvents like ethanol and PBS were examined for their effects on drug penetration, revealing that while ethanol alone was less effective, a cosolvent of ethanol-PBS improved drug delivery into viable skin layers. The research provided insights into the SC's role as a barrier and reservoir, the potential of NPs for targeted drug release, and the influence of solvents on drug localization within the skin.
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