TLDR Transcutol® helps drugs penetrate the skin more effectively in various formulations.
This review explores the use of Transcutol® (TRC) as a skin penetration and permeation enhancer in complex formulations such as patches, emulsions, vesicles, solid lipid nanoparticles, and micro or nanoemulsions. It highlights the mechanisms by which TRC and other hydroalcoholic solvents enhance drug delivery through the skin, focusing on drug diffusion, solubilization, and partitioning in the stratum corneum, as well as solvent drag for systemic absorption. The review emphasizes the importance of the interplay between drug properties, skin barrier function, and formulation parameters in achieving effective transdermal delivery.
26 citations
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