Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases

This review highlights the development of nanoemulgels as advanced topical and transdermal drug delivery systems for treating skin diseases. These novel formulations incorporate a variety of molecules, including marketed drugs, repurposed drugs, natural compounds, and synthetic molecules, to address conditions such as wound healing, infections, inflammatory diseases, skin cancer, neuropathy, and aging. The nanoemulgels demonstrate superior characteristics in terms of droplet size, stability, drug release, and permeation compared to existing products. In vitro and in vivo studies confirm their safety and efficacy, suggesting that these formulations could replace or complement current therapies and potentially reach the market to treat prevalent skin and systemic conditions.