Liposomes and Ethosomes: Comparative Potential in Enhancing Skin Permeability for Therapeutic and Cosmetic Applications

    November 2024 in “ Cosmetics ”
    Ewelina Musielak, Violetta Krajka‐Kuźniak
    TLDR Ethosomes enhance skin penetration better than liposomes, benefiting therapeutic and cosmetic applications.
    This review explores the potential of liposomes and ethosomes in enhancing skin permeability for therapeutic and cosmetic applications. Liposomes, consisting of a lipid bilayer, aid in drug penetration but struggle with the stratum corneum barrier, leading to the development of ethosomes. Ethosomes, with high ethanol content, effectively deliver drugs to deeper skin layers. They have been used with substances like methotrexate and vitamins A and E in cosmetics. A notable advancement is rutin-loaded ethosomes, which improve stability and skin penetration, benefiting anti-aging and anti-inflammatory products. The first clinical trial of acyclovir–ethosome formulations suggests further research is needed. The review highlights recent advances, including commercial formulations and clinical trials.
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