Unlocking Dithranol's Potential: Advanced Drug Delivery Systems for Improved Pharmacokinetics

This paper reviews advanced drug delivery systems designed to improve the pharmacokinetics of dithranol, a therapeutic agent for psoriasis, which is limited by poor stability and skin irritation in conventional formulations. It discusses the benefits of using nanoparticles, nanosuspensions, liposomes, and other systems to stabilize the drug and enhance delivery to target tissues. The paper also covers polymeric systems like hydrogels and micelles that improve solubility and sustain drug release. In-vitro and in-vivo studies are detailed, highlighting improved drug release kinetics and biodistribution. These advanced systems aim to overcome current formulation limitations, enhancing dithranol's therapeutic impact on psoriasis and other skin conditions.