Formulation Development of Drug Nanocrystals and Nanoparticles for Dermal Delivery

The document discussed the development of drug nanocrystals and nanoparticles for dermal delivery, emphasizing their ability to overcome solubility challenges of poorly soluble drugs. Nanocrystals, with 100% drug loading, enhanced saturation solubility and dissolution rates, benefiting dermal applications through increased concentration gradients and potential hair follicle targeting. The study used wet bead milling to prepare nanocrystals, finding that reduced crystallinity and nanosize improved solubility and dissolution rates. A novel method combining amorphous solid state and nanosize showed synergistic effects, significantly enhancing solubility and dissolution rates. Additionally, a new nanocarrier for controlled drug release was developed by encapsulating nanocrystals within a polymer shell, offering potential for prolonged drug exposure in treatments like psoriasis. The research highlighted the importance of maintaining the drug's solid state during processing and storage.