Advances in Nanocarrier Systems for Dermatologic Transdermal Drug Delivery: A Chemical and Molecular Review

This review highlights recent advancements in nanocarrier systems for transdermal drug delivery, focusing on their molecular design to overcome the barriers posed by the stratum corneum. It analyzes 64 studies on nanocarriers like liposomes and polymeric nanoparticles, discussing their applications in delivering drugs for conditions such as atopic dermatitis, psoriasis, acne, alopecia, and melanoma. The review emphasizes the importance of particle size, surface charge, and other chemical properties in optimizing these systems. Despite challenges in formulation stability and scalability, innovations such as AI-guided platforms show promise for precision therapy in dermatology, indicating significant potential for nanocarriers to transform dermatologic care.