Advances in Nanocarrier Systems for Dermatologic Transdermal Drug Delivery: A Chemical and Molecular Review

The document reviews recent advancements in nanocarrier systems for transdermal drug delivery in dermatology, focusing on overcoming the skin's barrier properties to improve treatment outcomes for various skin conditions. Innovations such as liposomes, ethosomes, microneedles, niosomes, polymeric nanoparticles, and lipid-based carriers like SLNs and NLCs enhance drug penetration, targeting, and release. These systems are particularly promising for conditions like alopecia, psoriasis, acne, and melanoma, offering targeted and sustained delivery with minimal systemic exposure. Challenges remain in formulation stability and regulatory complexities, but future directions include integrating precision medicine and smart nanocarriers to enhance personalized treatment.