A Multi-Technique Approach to the Study of Structural Stability and Desolvation of Two Unusual Channel Hydrate Solvates of Finasteride

    January 2012 in “ Journal of Pharmaceutical Sciences ”
    Stephen Byard, Anuji Abraham, Paul J. T. Boulton, Robin K. Harris, Paul Hodgkinson
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    TLDR Desolvation of finasteride depends on environment and technique.
    This document discusses a study on the structural stability and desolvation of two unusual channel hydrate solvates of finasteride. The study used a multi-technique approach, including solid-state nuclear magnetic resonance, powder X-ray diffraction, thermogravimetric analysis, and dynamic vapor sorption. The results showed that desolvation is not found to occur at a well-defined temperature or consistently produce the same anhydrous form, but is instead highly dependent on the physical environment and technique used. The study emphasizes the importance of understanding the desolvation behavior of solvates in pharmaceutical manufacturing.
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