A Multi-Technique Approach to the Study of Structural Stability and Desolvation of Two Unusual Channel Hydrate Solvates of Finasteride

January 2012 in “ Journal of Pharmaceutical Sciences ”

Stephen Byard, Anuji Abraham, Paul J. T. Boulton, Robin K. Harris, Paul Hodgkinson

finasteride solid-state nuclear magnetic resonance powder X-ray diffraction thermogravimetric analysis dynamic vapor sorption desolvation channel hydrate solvates Propecia NMR XRD TGA DVS

TLDR Desolvation of finasteride depends on environment and technique.

This document discusses a study on the structural stability and desolvation of two unusual channel hydrate solvates of finasteride. The study used a multi-technique approach, including solid-state nuclear magnetic resonance, powder X-ray diffraction, thermogravimetric analysis, and dynamic vapor sorption. The results showed that desolvation is not found to occur at a well-defined temperature or consistently produce the same anhydrous form, but is instead highly dependent on the physical environment and technique used. The study emphasizes the importance of understanding the desolvation behavior of solvates in pharmaceutical manufacturing.

View this study on jpharmsci.org →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Three Isostructural Solvates of Finasteride and Their Solid-State Characterization

21 citations, October 2009 in “European Journal of Pharmaceutical Sciences”

Three new finasteride solvates found, change forms under different drying conditions.

research Structural Study of Polymorphs and Solvates of Finasteride

61 citations, May 2007 in “Journal of Pharmaceutical Sciences”

Different forms of hair loss drug can improve effectiveness.

research Structural Characterization of Polymorphs and Molecular Complexes of Finasteride

17 citations, January 1999 in “Journal of Molecular Structure”

Finasteride's molecular and crystal structures help develop new drug formulations.

Related Community Posts Join

6 / 1000+ results

community How to Switch from Finasteride to Dutasteride according to literature.

in Research/Science 53 upvotes 6 months ago

Switching from finasteride to dutasteride involves gradually increasing dutasteride while decreasing finasteride. Studies show dutasteride 0.5 mg daily can improve hair density in men unresponsive to finasteride.

community How possible is temple regrowth really?

in Minoxidil 48 upvotes 9 months ago

A person started using finasteride, minoxidil, and dermarolling to regrow hair at the temples and is asking if it's possible. Some users report temple regrowth is possible with these treatments, while others find it challenging, and advise consistency and patience with treatment.

community If you're sitting there wondering, "I'm losing my hair, what do I do?" then read my advice here. I've been fighting the fight for 7 years, with great success. (pictures included)

in Question 109 upvotes 11 years ago

Fighting hair loss with "The Big 3" treatments of Propecia, Rogaine and Nizoral shampoo, as well as specific advice on how to use these products. People have shared their long-term success stories and some have discussed the side effects of finasteride. Other suggestions included Lipogaine and Pura D'or Hair Loss Prevention Therapy Shampoo & Conditioner.

community Embraced baldness. Time to leave this subreddit

in Chat 876 upvotes 4 months ago

A user shared their positive experience of embracing baldness after years of trying treatments like Minoxidil and finasteride. They found happiness and confidence by shaving their head, despite some social challenges, and encouraged others to focus on their attitude and seek therapy if needed.

community Hair loss treatment rabbit hole [OC]

in Satire 317 upvotes 2 years ago

Hair loss treatments, ranging from topical minoxidil and finasteride to taking hormones such as estradiol or nandrolone, as well as a controversial suggestion of an orchiectomy. A hair system is also mentioned as an alternative solution.

community A hair model who does beauty ads and has 3 million followers claims he went from almost a Norwood 3 to a perfect hairline in 8 months on only Minoxidil and Rosemary oil. Curious, what are people’s thoughts?

in Chat 1 year ago

This conversation discusses the results of a model who claims he went from almost a Norwood 3 to a perfect hairline in 8 months using only Minoxidil and Rosemary oil. The replies suggest that this could be realistic but long-term results would require additional treatments like finasteride or other medications to prevent further hair loss.

Related Research

1 / 1 results

A Multi-Technique Approach to the Study of Structural Stability and Desolvation of Two Unusual Channel Hydrate Solvates of Finasteride

research A Multi-Technique Approach to the Study of Structural Stability and Desolvation of Two Unusual Channel Hydrate Solvates of Finasteride

21 citations, January 2012 in “Journal of Pharmaceutical Sciences”

Desolvation of finasteride depends on environment and technique.