A Multi-Technique Approach to the Study of Structural Stability and Desolvation of Two Unusual Channel Hydrate Solvates of Finasteride

September 2011 in “ Journal of Pharmaceutical Sciences ”

Stephen Byard, Anuji Abraham, Paul J. T. Boulton, Robin K. Harris, Paul Hodgkinson

finasteride solid-state nuclear magnetic resonance powder X-ray diffraction thermogravimetric analysis dynamic vapor sorption desolvation channel hydrate solvates Propecia NMR XRD TGA DVS

Studysummary This study found that the desolvation of finasteride hydrate solvates is highly dependent on the physical environment, complicating investigations but providing insight through complementary analysis techniques. Our plain-language summary of this paper — not a Tressless recommendation.

This document discusses a study on the structural stability and desolvation of two unusual channel hydrate solvates of finasteride. The study used a multi-technique approach, including solid-state nuclear magnetic resonance, powder X-ray diffraction, thermogravimetric analysis, and dynamic vapor sorption. The results showed that desolvation is not found to occur at a well-defined temperature or consistently produce the same anhydrous form, but is instead highly dependent on the physical environment and technique used. The study emphasizes the importance of understanding the desolvation behavior of solvates in pharmaceutical manufacturing.

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