Use of Rotary Echoes in ²H Magic-Angle Spinning NMR for the Quantitative Study of Molecular Dynamics
May 2009
in “
Chemical Physics Letters
”
TLDR A new method accurately measures molecular movement without complex modeling.
The study analyzed the interaction of sample spinning and chemical dynamics using 2H magic-angle spinning NMR, focusing on the conformational exchange of 1,4-dioxane in a solvate with finasteride. It demonstrated that a metric based on the intensity of rotational echoes could derive kinetic information without full NMR response modeling. This approach provided an activation barrier consistent with previous estimates, despite the challenges posed by the anisotropic tumbling of solvent molecules. The research highlighted the advantages of magic-angle spinning, such as increased signal-to-noise ratio and sensitivity to a broader range of dynamic frequency scales, over static sample analysis.
