Image

    Upcycled Postbiotic Cell-Free Supernatants from Limosilactobacillus Fermentum MG901 and MG4237 Alleviated Oxidative Stress-Induced Dysfunction in Human Follicle Dermal Papilla Cells

    February 2026 in “ Cosmetics ”
    Chae Young Jeon, Ji Yeon Lee, Jungwon Min … Dong Wook Shin
    Studysummary This study found that upcycled postbiotic cell-free supernatants from Limosilactobacillus fermentum MG901 and MG4237 protected human dermal papilla cells from oxidative stress, enhancing wound-healing capacity and mitochondrial function, suggesting potential as a sustainable cosmetic ingredient for hair loss alleviation.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 28

    1. Anti-Hair Loss Effect of Veratric Acid on Dermal Papilla Cells International Journal of Molecular Sciences · 2025
    2. Hair Growth-Promoting Effects of Astragalus Sinicus Extracts in Human Follicle Dermal Papilla Cells Cosmetics · 2025
    3. Dermal Papilla Cells: From Basic Research to Translational Applications Biology · 2024
    4. Exosomes Derived From Mouse Vibrissa Dermal Papilla Cells Promote Hair Follicle Regeneration During Wound Healing By Activating Wnt/β-Catenin Signaling Pathway Journal of Nanobiotechnology · 2024
    5. Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells International Journal of Molecular Sciences · 2024
    6. Oxidative Stress in Hair Follicle Development and Hair Growth: Signaling Pathways, Intervening Mechanisms and Potential of Natural Antioxidants Journal of Cellular and Molecular Medicine · 2024
    7. Efficacy of 5% Topical Minoxidil Versus 5 Mg Oral Biotin Versus Topical Minoxidil and Oral Biotin on Hair Growth in Men: Randomized, Crossover, Clinical Trial Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2024
    8. Retinoic Acid Drives Hair Follicle Stem Cell Activation via Wnt/Beta-Catenin Signalling in Androgenetic Alopecia JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    9. Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells Journal of Microbiology and Biotechnology · 2024
    10. Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production International journal of molecular sciences · 2023
    11. Observations Suggesting a Contribution of Altered Dermal Papilla Mitochondrial Function to Androgenetic Alopecia Experimental Dermatology · 2022
    12. Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway Journal of Microbiology and Biotechnology · 2021
    13. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    14. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Skin Pharmacology and Physiology · 2020
    15. Overexpression of Alkaline Phosphatase Improves the Hair-Inductive Capacity of Cultured Human Dermal Papilla Spheres Journal of Dermatological Science · 2019
    16. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    17. Androgenetic Alopecia: A Review Endocrine · 2017
    18. Stress-Induced Premature Senescence of Dermal Papilla Cells Compromises Hair Follicle Epithelial-Mesenchymal Interaction Journal of Dermatological Science · 2017
    19. CD133-Positive Dermal Papilla-Derived Wnt Ligands Regulate Postnatal Hair Growth Biochemical Journal · 2016
    20. Activating Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Increases Hair Inductivity FEBS Journal · 2016
    21. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
    22. Arctiin Blocks Hydrogen Peroxide-Induced Senescence and Cell Death Through MicroRNA Expression Changes in Human Dermal Papilla Cells Biological Research · 2014
    23. Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells Stem Cells Translational Medicine · 2014
    24. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    25. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    26. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
    27. Male Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2010
    28. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010