Efficacy of 5% Topical Minoxidil Versus 5 Mg Oral Biotin Versus Topical Minoxidil and Oral Biotin on Hair Growth in Men: Randomized, Crossover, Clinical Trial

A randomized, crossover, clinical trial was conducted on 10 healthy male participants to evaluate the effectiveness of oral biotin (5 mg daily), topical minoxidil (5% twice daily), and a combination of both in increasing hair growth rate (HGR). The interventions were applied for a period of 14 days each. The results showed a significant increase in HGR and the photographic area covered by hair only in the group that used the combination of topical minoxidil and oral biotin. The isolated use of both substances did not present a positive result in increasing growth velocity. The study suggests a potential synergistic effect of biotin and minoxidil on hair growth, but more studies are needed to analyze the benefit of long-term use of the combination.