Tissue Repair and Stress Responses of Aged Skin Epidermis

The study "Tissue repair and stress responses of aged skin epidermis" conducted by Wesley Wong in 2020 investigated the effects of aging on the skin's epidermis, particularly focusing on the role of cellular metabolism. The research found that the epidermis becomes dysregulated with age, leading to issues such as wrinkling, hair loss, and impaired wound healing. The study also revealed that the exercise-induced cytokine IL-15 could improve wound healing in aged skin and had positive effects on skin structure and mitochondria. Additionally, the research described a mouse model with bioenergetic disruptions in the basal epidermis, which resulted in skin repair defects and altered differentiation. The study also explored the biology of Acomys, an organism with superior epidermal regeneration, and found that it formed a distinct skin structure that resisted the effects of solar radiation.