Synergistic Treatment of Androgenetic Alopecia with Follicular Co-Delivery of Minoxidil and Cedrol in Metal-Organic Frameworks Stabilized by Covalently Cross-Linked Cyclodextrins

    February 2024 in “ International Journal of Pharmaceutics ”
    Zhiyao He, Yongtai Zhang, Zhenda Liu, Teng Guo, Xinyi Ai, Yuanzhi He, Xinjuan Hou, Nianping Feng
    Image of study
    TLDR A new hair loss treatment combining minoxidil and cedrol improves hair growth and reduces side effects.
    The study developed a new hair follicle delivery system, MXD-CED@CDF, loaded with minoxidil and cedrol for effectively treating Androgenetic Alopecia (AGA). This system reduced the adverse reaction of minoxidil, improved drug release and follicular delivery performance, enhanced human dermal papilla cells' (hDPCs) viability and uptake of drugs, and developed biocompatibility with skin. It also presented premature initiation and prolongation of the anagen phase in the hair cycle, hair follicle differentiation, and hair regeneration. The study used human dermal papilla cells, male C57BL/6 mice, and New Zealand white rabbits for the experiments. The synergistic effect of minoxidil and cedrol showed excellent results in promoting hDPCs viability and treating AGA in C57BL/6 mice.
    Discuss this study in the Community →

    Research cited in this study

    34 / 34 results

    Related Community Posts Join

    6 / 1000+ results

      community Minoxidil results - Starts July 7

      in Minoxidil  294 upvotes 4 days ago
      The conversation discusses the use of topical minoxidil for hair loss, with the original poster sharing positive results after three months of use without finasteride. Many users suggest adding finasteride to maintain gains, while others share their experiences and concerns about side effects and application methods.

      community Can oral minoxidil cause significant changes in blood pressure? (deprecated thread)

      in Minoxidil  214 upvotes 1 week ago
      The user is using oral minoxidil and dutasteride for hair loss and observed changes in blood pressure after taking oral minoxidil. They experienced no visible symptoms from topical minoxidil, finasteride, or other treatments and are seeking feedback on whether these blood pressure changes are typical for oral minoxidil users.

      community Hair has only gotten worse ~10 months on minoxidil.

      in Minoxidil  1 upvotes 2 weeks ago
      The user experienced worsening hair loss despite using finasteride and topical minoxidil, and is considering switching to dutasteride and oral minoxidil. They also tried microneedling and tretinoin with minoxidil, and are exploring Sulfogenz topical minoxidil.

      community Let's talk about the use of minoxidil 15%

      in Minoxidil  3 upvotes 2 weeks ago
      Minoxidil 5% is no longer effective for the user, who is considering stronger minoxidil or oral options despite availability issues. Suggestions include trying minoxidil 15%, oral minoxidil, microneedling, and exploring other treatments like finasteride and dutasteride.

    Related Research

    1 / 1 results