Synergistic Treatment of Androgenetic Alopecia with Follicular Co-Delivery of Minoxidil and Cedrol in Metal-Organic Frameworks Stabilized by Covalently Cross-Linked Cyclodextrins

    February 2024 in “ International Journal of Pharmaceutics ”
    Zhiyao He, Yongtai Zhang, Zhenda Liu, Teng Guo, Xinyi Ai, Yuanzhi He, Xinjuan Hou, Nianping Feng
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    TLDR A new hair loss treatment combining minoxidil and cedrol improves hair growth and reduces side effects.
    The study developed a new hair follicle delivery system, MXD-CED@CDF, loaded with minoxidil and cedrol for effectively treating Androgenetic Alopecia (AGA). This system reduced the adverse reaction of minoxidil, improved drug release and follicular delivery performance, enhanced human dermal papilla cells' (hDPCs) viability and uptake of drugs, and developed biocompatibility with skin. It also presented premature initiation and prolongation of the anagen phase in the hair cycle, hair follicle differentiation, and hair regeneration. The study used human dermal papilla cells, male C57BL/6 mice, and New Zealand white rabbits for the experiments. The synergistic effect of minoxidil and cedrol showed excellent results in promoting hDPCs viability and treating AGA in C57BL/6 mice.
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