PRP in Combination Therapy for Hair Loss (AGA)

January 2021 in “ Springer eBooks ”

Geraldine Cheyana Ranasinghe, Wilma F. Bergfeld

Platelet-Rich Plasma Androgenetic Alopecia minoxidil finasteride combination therapy PRP AGA Rogaine Propecia

TLDR Combining PRP with other treatments can improve hair loss outcomes.

The document discussed the use of Platelet-Rich Plasma (PRP) as an additional therapy for treating Androgenetic Alopecia (AGA), highlighting its potential to improve outcomes when combined with treatments like minoxidil and finasteride. It emphasized the challenges in creating effective regimens due to limited options and varying patient tolerance, aiming to enhance the quality of life for AGA patients through combination therapy.

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research Stratifying Clinical Response to Adjuvant Platelet-Rich Plasma in Patients with Androgenetic Alopecia

3 citations , April 2020 in “British Journal of Dermatology”

PRP treatment helps 70.1% of hair loss patients after two sessions.

research A Review of the Treatment of Male Pattern Hair Loss

53 citations , February 2020 in “Expert Opinion on Pharmacotherapy”

Finasteride and minoxidil work best together for hair loss.

research Topical Ketoconazole for the Treatment of Androgenetic Alopecia: A Systematic Review

11 citations , January 2020 in “Dermatologic Therapy”

Ketoconazole may help regrow hair and increase follicle size, but more research needed.

research Platelet-Rich Plasma and Microneedling Improve Hair Growth in Patients with Androgenetic Alopecia When Used as an Adjuvant to Minoxidil

24 citations , October 2019 in “Journal of Cosmetic Dermatology”

Combining platelet-rich plasma, microneedling, and minoxidil improves hair growth.

research Androgenetic Alopecia and Microneedling: Every Needling Is Not Microneedling

5 citations , August 2019 in “Journal of The American Academy of Dermatology”

Microneedling improves hair growth in androgenetic alopecia when combined with minoxidil.

research Platelet-Rich Plasma and Stem Cells for Hair Growth: A Review of the Literature

12 citations , May 2019 in “Aesthetic Surgery Journal”

Platelet-Rich Plasma and stem cell therapy can increase hair count and density, but the best method for preparation and treatment still needs to be determined.

research Treatment of Male Pattern Alopecia with Platelet-Rich Plasma: A Double-Blind Controlled Study with Analysis of Platelet Number and Growth Factor Levels

57 citations , March 2019 in “Journal of The American Academy of Dermatology”

Platelet-rich plasma treatment can significantly increase hair count and density in men with pattern baldness, and these improvements can last up to 3 months.

research Treatment of Female Pattern Hair Loss with Combination Therapy

2 citations , December 2018 in “Seminars in Cutaneous Medicine and Surgery”

research Evaluating the Efficacy of Different Platelet-Rich Plasma Regimens for Management of Androgenetic Alopecia: A Single-Center, Blinded, Randomized Clinical Trial

46 citations , September 2018 in “Dermatologic Surgery”

PRP injections effectively treat hair loss, with positive results in both monthly and every three months treatments.

research Platelet-Rich Plasma for the Management of Hair Loss: Better Alone or in Combination?

12 citations , June 2018 in “Journal of Cosmetic Dermatology”

PRP is effective for hair loss and might work better with other treatments, but more research is needed.

research Platelet-Rich Plasma with Microneedling in Androgenetic Alopecia Along with Dermoscopic Pre- and Post-Treatment Evaluation

36 citations , June 2018 in “Journal of Cosmetic Dermatology”

PRP with microneedling effectively treats hair loss, and dermoscopy helps evaluate results.

research The Effect of Autologous Activated Platelet-Rich Plasma Injection on Female Pattern Hair Loss: A Randomized Placebo-Controlled Study

52 citations , February 2018 in “Journal of Cosmetic Dermatology”

PRP injections improve hair density and thickness in women with hair loss.

research Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone

80 citations , January 2018 in “International Journal of Dermatology”

Low-dose oral minoxidil and spironolactone combo effectively reduces hair loss and improves hair density in women.

research A Proposal of an Effective Platelet-Rich Plasma Protocol for the Treatment of Androgenetic Alopecia

19 citations , October 2017 in “International Journal of Trichology”

The document concludes that injecting platelet-rich plasma can effectively treat androgenetic alopecia, a type of hair loss.

research Platelet-Rich Plasma in Combination With 5% Minoxidil Topical Solution and 1 mg Oral Finasteride for the Treatment of Androgenetic Alopecia: A Randomized Placebo-Controlled, Double-Blind, Half-Head Study

19 citations , May 2017 in “Dermatologic Surgery”

Combining platelet-rich plasma with 5% minoxidil solution improves hair regrowth in androgenetic alopecia patients.

research A Split Head Study of Efficacy of Placebo Versus Platelet-Rich Plasma Injections in the Treatment of Androgenic Alopecia

33 citations , April 2017 in “Journal of Cutaneous and Aesthetic Surgery”

Platelet-rich plasma injections can effectively treat male pattern hair loss, improving hair density and quality with high patient satisfaction.

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations , February 2017 in “International Journal of Molecular Sciences”

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

research Meta-Analysis of Efficacy of Platelet-Rich Plasma Therapy for Androgenetic Alopecia

57 citations , January 2017 in “Journal of Dermatological Treatment”

PRP therapy may effectively treat hair loss, but more research needed.

research A Comparative Study of Microneedling with Platelet-Rich Plasma Plus Topical Minoxidil (5%) and Topical Minoxidil (5%) Alone in Androgenetic Alopecia

48 citations , January 2017 in “International Journal of Trichology”

Microneedling with platelet-rich plasma and minoxidil improves hair growth more than just minoxidil in men with hair loss.

research A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia

60 citations , December 2016 in “Dermatologic Surgery”

PRP treatment may stimulate hair growth by promoting blood vessel formation, increasing growth factors, and preventing cell death.

research Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia

87 citations , November 2016 in “Dermatologic Surgery”

PRP shows potential for treating female hair loss, but more research needed.

research Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic (Male-Patterned) Alopecia: A Pilot Randomized Controlled Trial

61 citations , October 2016 in “Journal of Cosmetic and Laser Therapy”

Platelet-rich plasma (PRP) was found not effective in treating male-patterned hair loss.

research Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

136 citations , April 2016 in “Dermatologic Surgery”

PRP treatment helps hair growth and density in androgenetic alopecia patients.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations , September 2015 in “Stem Cells Translational Medicine”

Platelet-rich plasma injections significantly improved hair regrowth and thickness in patients with hair loss.

research Androgenetic Alopecia: New Insights Into the Pathogenesis and Mechanism of Hair Loss

33 citations , August 2015 in “F1000Research”

New model shows muscle affects hair loss differently in men and women.

research Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

164 citations , October 2014 in “Journal of Cutaneous and Aesthetic Surgery”

PRP injections increase hair density and satisfaction in androgenetic alopecia patients.

research Efficacy and Safety of a Low-Level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-Controlled, Double-Blind Study

147 citations , January 2014 in “American Journal of Clinical Dermatology”

Laser device increases hair density, safe for treating hair loss in men and women.

research The Effect of CD34+ Cell-Containing Autologous Platelet-Rich Plasma Injection on Pattern Hair Loss: A Preliminary Study

88 citations , January 2014 in “Journal of The European Academy of Dermatology and Venereology”

Injecting CD34+ cell-containing platelet-rich plasma into the scalp can improve hair count and thickness in people with pattern hair loss.

research The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

183 citations , January 2014 in “BioMed Research International”

AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.

research HairMax LaserComb Laser Phototherapy Device in the Treatment of Male Androgenetic Alopecia

160 citations , January 2009 in “Clinical Drug Investigation”

HairMax LaserComb® effectively promotes hair growth and stops hair loss in males with androgenetic alopecia, with no serious side effects.

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

171 citations , February 2008 in “Journal of Investigative Dermatology”

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

research The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men

195 citations , May 2007 in “The Journal of Clinical Endocrinology and Metabolism”

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

research The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

215 citations , December 2006 in “Journal of The American Academy of Dermatology”

Dutasteride more effective for hair growth, but has more side effects than finasteride.

research The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

251 citations , November 2006 in “Plastic and reconstructive surgery/PSEF CD journals”

Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.

research Fortnightly Review: Male Pattern Androgenetic Alopecia

179 citations , September 1998 in “BMJ”

Hair loss in men is common, treatable, but not curable.

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects

222 citations , October 1993 in “Journal of The American Academy of Dermatology”

Hair loss affects women's mental health more than men's, causing anxiety, low self-esteem, and social insecurity.