The Use of Phosphodiesterase Inhibitors for the Treatment of Alopecia

    April 2019 in “ Journal of Dermatological Treatment ”
    Margit Juhasz, Natasha Atanaskova Mesinkovska
    Studysummary This review discusses the use of phosphodiesterase inhibitors for alopecia, finding promising preliminary results with topical caffeine for androgenetic alopecia and telogen effluvium, but limited success in alopecia areata.
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    Research cited in this study 20

    1. Efficacy of a Cosmetic Phyto-Caffeine Shampoo in Female Androgenetic Alopecia Giornale italiano di dermatologia e venereologia · 2020
    2. A Randomized Placebo-Controlled Single-Center Pilot Study of the Safety and Efficacy of Apremilast in Subjects with Moderate-to-Severe Alopecia Areata Archives of dermatological research · 2018
    3. Novel Effect of Sildenafil on Hair Growth Biochemical and Biophysical Research Communications · 2018
    4. The Effect of Cilostazol, a Phosphodiesterase 3 (PDE3) Inhibitor, on Human Hair Growth with Dual Promoting Mechanisms Journal of Dermatological Science · 2018
    5. Lack of Efficacy of Apremilast in 9 Patients with Severe Alopecia Areata Journal of the American Academy of Dermatology · 2017
    6. The Effect of Cilostazol on Hair Growth: A Novel Therapeutic Option for the Treatment of Hair Loss Journal of Investigative Dermatology · 2017
    7. An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% Versus Minoxidil 5% Solution in Male Androgenetic Alopecia Skin Pharmacology and Physiology · 2017
    8. A Novel Therapeutic Paradigm for Patients with Extensive Alopecia Areata Expert Opinion on Biological Therapy · 2016
    9. Extensive Alopecia Areata Is Reversed by IL-12/IL-23p40 Cytokine Antagonism The Journal of Allergy and Clinical Immunology · 2015
    10. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
    11. The PDE4 Inhibitor, Apremilast, Suppresses Experimentally Induced Alopecia Areata in Human Skin In Vivo Journal of Dermatological Science · 2014
    12. Dermal Nanocrystals from Medium Soluble Actives: Physical Stability and Stability Affecting Parameters European journal of pharmaceutics and biopharmaceutics · 2014
    13. Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro British Journal of Dermatology · 2014
    14. Nanocrystals of Medium Soluble Actives: Novel Concept for Improved Dermal Delivery and Production Strategy International journal of pharmaceutics · 2014
    15. Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2009
    16. The Role of Hair Follicles in the Percutaneous Absorption of Caffeine BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2007
    17. Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation Skin Pharmacology and Physiology · 2007
    18. Effect of Caffeine and Testosterone on the Proliferation of Human Hair Follicles In Vitro International Journal of Dermatology · 2007
    19. Caffeine Improves Barrier Function in Male Skin International Journal of Cosmetic Science · 2006
    20. Determination of the Sildenafil Effect on Alopecia Areata in Childhood: An Open-Pilot Comparison Study Journal of Dermatological Treatment · 2006

    Related research 7

    1. Potential Herbal Medicine for Alopecia Areata Treatment: A Systematic Review International journal of research publications · 2022
    2. Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis Journal of Cosmetic Dermatology · 2020
    3. The Efficacy of Topical Minoxidil for Non-Scarring Alopecia: A Systematic Review PubMed · 2019
    4. Off-Label Use of Topical Minoxidil in Alopecia: A Review American Journal of Clinical Dermatology · 2019
    5. Alopecia Areata: Evidence-Based Treatments Seminars in cutaneous medicine and surgery · 2009
    6. Alopecia Areata Treated With Topical Minoxidil Archives of Dermatology · 1984
    7. Topical Minoxidil in the Treatment of Alopecia Areata BMJ · 1983