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research Efficacy of Oral Apremilast in The Treatment of Alopecia Areata, at The Tertiary Care Hospital, Karachi

December 2023 in “Journal of health and rehabilitation research”

In this study conducted at a tertiary care hospital in Karachi, oral Apremilast significantly reduced the severity of alopecia areata, shown by a notable decrease in SALT Scores over 12 weeks, suggesting it may be an effective alternative treatment option for this condition.

research Comparing the efficacy of oral apremilast, intralesional corticosteroids, and their combination in patients with patchy alopecia areata: a randomized clinical controlled trial

4 citations , December 2024 in “Archives of Dermatological Research”

research Apremilast for Lichen Planopilaris and Frontal Fibrosing Alopecia: A Case Series

1 citations , June 2017 in “Skin”

This study is the first to report that apremilast may be effective in treating refractory lichen planopilaris and frontal fibrosing alopecia, though some patients experienced adverse effects leading to discontinuation.

research Comparative efficacy of oral Janus kinase inhibitors and biologics in adult alopecia areata: A systematic review and Bayesian network meta‐analysis

20 citations , January 2024 in “Journal of the European Academy of Dermatology and Venereology”

This study conducted a meta-analysis and found that among therapies for alopecia areata, baricitinib_4 mg was most likely to be effective, followed by ritlecitinib and ivarmacitinib, while other treatments like dupilumab and secukinumab were less effective.

research The use of phosphodiesterase inhibitors for the treatment of alopecia

3 citations , April 2019 in “Journal of Dermatological Treatment”

This review discusses the use of phosphodiesterase inhibitors for alopecia, finding promising preliminary results with topical caffeine for androgenetic alopecia and telogen effluvium, but limited success in alopecia areata.

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community Hair Loss “Cure” for Inflammation: Topical Roflumilast

in Research/Science 32 upvotes 8 months ago

Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

community The Worst Hair Loss Condition You (MAY) have: LPP

48 upvotes 2 years ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community People in Canada where are you guys getting oral minoxidil from?

11 upvotes 4 days ago

Oral minoxidil is difficult to find in Canadian pharmacies, with many users suggesting online options like Essential Clinic, Phoenix, and UpGuys. Some users mention alternatives like compounding pharmacies or specific locations like Costco and Rexall.

community Oral minoxidil users, for your interest

61 upvotes 5 days ago

Taking oral minoxidil in the morning may lead to better hair growth results compared to taking it at night. Some users combine it with finasteride and topical treatments, and there are discussions about splitting doses or adjusting timing to maximize benefits.

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Learn

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learn mometasone furoate

learn Beclomethasone

learn Desoximetasone

learn Triamcinolone Acetonide

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. Topical finasteride offers localized treatment with fewer systemic side effects than oral finasteride.

learn Metformin

Is metformin used topically for hair loss, or only as an oral tablet? Approved metformin products are oral tablets only; there is no approved topical metformin for hair loss. Published human reports of topical use are a handful of uncontrolled, pharmacy-compounded case reports in scarring alopecia, and the most-cited clinical series actually used the oral drug.

learn Sulforaphane

Is sulforaphane used in oral supplements or topical hair treatments? Sulforaphane is primarily used in oral supplements, not topical hair treatments.

learn white tea

Is white tea more effective in topical hair products or as an oral supplement for hair growth? Neither topical nor oral white tea has any human clinical trial behind it for hair growth. Topical use has a more direct mechanistic rationale, but the only verifiable studies are a cell-culture EGCG experiment and a pharmacokinetic study with no hair outcomes.

learn Estradiol

How does topical Estradiol compare to oral Estradiol in treating alopecia? Topical estradiol delivers hormone to the scalp with less systemic exposure, but evidence is thin and it is still a hormone. It needs a doctor's supervision, and people with estrogen-sensitive cancers must not use it without medical approval.

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