Nothopanax Scutellarium: Natural Hair Growth Plant

The study on mangkokan leaves (Nothopanax scutellarium) highlights their potential in promoting hair growth due to their flavonoid content, especially quercetin. A review of 68 articles, with 5 meeting the criteria, shows that formulations like ethosomal gel or phytosome lotion at a 25% concentration are most effective. These formulations work by activating eNOS, regulating NO balance, reducing inflammation, inhibiting 5-alpha reductase to lower DHT levels, and increasing growth factors like IGF-1, VEGF, KGF, and HGF. These actions help extend the anagen phase and improve hair health, indicating that mangkokan leaves could be a valuable ingredient in hair care products. Further research is needed to confirm their long-term safety and effectiveness.