2 citations
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November 2021 in “International Journal of Applied Pharmaceutics” This study found that a phytosome lotion made from Mangkokan leaf extract, using a green solvent and microwave-assisted extraction, demonstrated greater hair growth activity than 2% minoxidil, with the 30% phytosome lotion showing the highest efficacy in increasing hair length, weight, and diameter.
1 citations
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August 2019 In this study, a hair tonic formulation with 25% ethanol extract of mangkokan leaves showed effectiveness in promoting hair growth, as measured by significant differences in hair length and weight compared to the control.
1 citations
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November 2017 in “JFL : Jurnal Farmasi Lampung” In this study, researchers found that hair tonic formulations containing Nothopanax scutellarium extract enhanced hair growth in male rabbits over 21 days, with the 25% concentration showing comparable effects to a minoxidil-based positive control.
1 citations
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August 2017 in “Asian Journal of Pharmaceutical and Clinical Research” The 1% ethyl acetate fraction ethosomal gel from Nothopanax scutellarium leaves promotes hair growth but can mildly irritate the skin.
June 2025 in “Pharmacon Jurnal Farmasi Indonesia” This systematic review found that mangkokan leaf formulations, especially ethosomal gel or phytosome lotion at 25% concentration, were most effective in stimulating hair growth and improving hair health through various biological mechanisms.