Role of Non-Androgenic Factors in Hair Loss and Hair Regrowth

The 2017 document discusses the significance of non-androgenic factors in hair loss and hair regrowth, highlighting the impact of nutritional, environmental, and lifestyle factors on hair follicles. It points out that antioxidants can counteract the negative effects of Reactive Oxygen Species (ROS) and Transforming Growth Factor (TGF) β1, which are induced by androgens and inhibit hair growth. The paper also connects calorie restriction and micronutrient deficiencies to autophagy and apoptosis, which may lead to the cessation of hair growth. It emphasizes the importance of micronutrients such as zinc, copper, selenium, and vitamins A, C, and D in hair health. The document concludes that a well-planned nutritional program can be effective in strengthening and regrowing hair without the need for medications like Finasteride. Additionally, it supports the use of vitamin B6, calcium pentothenate, l-cystine, and l-lysine, based on double-blind placebo-controlled trials, and warns against the potential hair loss associated with vegetarian and lacto-vegetarian diets. It also raises concerns about endocrine-disrupting chemicals and the reduced nutritional value of foods due to modern farming practices. The author's clinical experience suggests that low-dose nutritional correction can improve hair loss management for both men and women, without relying on anti-androgens or minoxidil. The overall conclusion is that good nutritional balance is essential for hair health and should be considered alongside anti-androgens in hair loss management.