Systemic Therapy of Diffuse Effluvium and Hair Structure Damage

    June 1993 in “ PubMed
    Budde J, H. Tronnier, V.W. Rahlfs, S. Frei-Kleiner
    Studysummary This study found that a vitamin B-group and L-cystine combination therapy improved hair quality and growth in women with diffuse effluvia, with one formulation showing greater efficacy than another and both performing better than placebo.
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    A controlled randomized double-blind study was conducted with 72 female patients to evaluate the tolerance and efficacy of two therapeutic agents containing B-group vitamins and L-cystine, compared to a placebo, for treating diffuse effluvium and hair structure damage. The study measured hair quality through hair swelling and hair growth via frontal and parietal anagen rates in trichograms over 4 months. Active medication 1 showed statistically significant superiority over the placebo, while active medication 2 was better than the placebo but less effective than active medication 1. The additional ingredients in active medication 1 contributed to its higher efficacy, which could not be matched by the increased L-cystine in active medication 2. Both active medications were well-tolerated with no adverse effects observed.
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