Dissolving Microneedle Patch Loading Dutasteride Microspheres for the Long-Acting Treatment of Androgenetic Alopecia

This review summarizes the application of microneedles in treating various skin diseases and highlights challenges like low drug loading, noting no new clinical results are reported.

Low-dose oral minoxidil alone is effective for treating hair loss, but combining it with dutasteride or finasteride may offer better results.

This study found that cedrol nanoemulsions significantly promote hair follicle regeneration and reduce DHT levels in an androgenic alopecia mouse model, suggesting potential efficacy in AGA treatment.

This study found that extracellular vesicles derived from hyaluronic acid-stimulated induced pluripotent stem cells significantly improved hair growth in a model of androgenetic alopecia in mice by enhancing Wnt/β-catenin signaling and regulating androgen receptor activity, showing comparable results to the commonly used treatment finasteride.

This review explores how microneedles can improve the delivery of dermatological treatments by bypassing the skin's outer barrier, discussing their potential use in managing skin diseases, cosmetic applications, and challenges related to clinical adoption.

This study reported that newly developed minoxidil Pickering emulsion gels, designed using cellulose stabilizers, showed promising results for promoting hair regrowth and targeting hair follicles by enhancing the delivery and stabilization properties of the formulation in a hair loss treatment context.

In a study using an AGA mouse model, researchers observed that a novel topical gel combining hybrid extracellular vesicles, gold nanoparticles, and finasteride accelerated hair regrowth and improved hair quality more effectively than conventional minoxidil treatment, presenting a promising option with fewer side effects.

This study found that a 2-deoxy-D-ribose gel stimulated hair follicle growth in mice with androgenic alopecia, showing effects similar to minoxidil without additional benefits from combining the two treatments.

This study developed a personalized microneedle that delivers finasteride directly to the skin, facilitating a sustained release and potentially reducing side effects associated with oral administration.

Taking medication for hair loss might cause sexual problems.

This research emphasizes the importance of understanding patient experiences related to hair loss, highlighting that race, ethnicity, culture, resources, and mental health greatly affect these experiences. Effective counseling involves clear communication, validation, and shared decision-making to provide appropriate treatment, support, or camouflage options.

This study reports that a water-soluble microneedle patch with minoxidil-loaded microspheres showed similar or better hair regeneration effects in mice with less frequent application compared to daily topical minoxidil.

This study found that collagen peptides from Mozambique tilapia significantly promoted hair regrowth and increased the proliferation of hair growth factors in vitro and in vivo, suggesting potential as supplements for hair loss prevention.

This study reports no results yet and only indicates an ongoing randomized placebo-controlled trial investigating the effects of microneedling combined with topical dutasteride solution for treating androgenetic alopecia.

In this study, a novel topical bimatoprost formulation (BIM-TF#5) significantly enhanced hair regrowth and increased dermal drug deposition in both human skin models and an androgenic alopecia mouse model compared to previous preparations.

This study demonstrated that a finasteride-loaded proniosome significantly enhanced transfollicular delivery and hair growth in mice without causing skin irritation, with effects comparable to a 2% minoxidil solution.

This study found that a ceria nanozyme-integrated microneedles patch accelerated hair regeneration in an androgenetic alopecia mouse model more effectively than minoxidil, with reduced application frequency and minimal skin damage.

In this study, intradermal injections of 0.5% minoxidil significantly improved hair growth and volume in women with female androgenetic alopecia compared to a placebo, with a good safety profile reported.

In this study, microneedles combined with finasteride nanostructured lipid carriers (FIN-NLC-MNs) were found to enhance skin penetration and specifically target hair follicles, promoting hair growth and gene regulation in androgenetic alopecia.

In this study, researchers developed a new self-administered finasteride delivery system using powder-carrying microneedles that improved hair growth efficacy and addressed safety concerns compared to topical finasteride gel by allowing sustained intradermal release of the drug for three days with a single application.

This review discusses female androgenetic alopecia, highlighting its diagnostic challenges and management strategies, but it reports no new results.

This review discusses the physiopathology of androgenetic alopecia and evaluates various traditional and emerging treatments, reporting no new clinical results but highlighting the need for enhanced treatment strategies.

This study found that mechanical skin stretching can stimulate hair stem cell proliferation and hair regeneration by activating a complex pathway involving WNT, BMP-2, and M2 macrophages.

In a mouse model, this study demonstrated that a microneedle patch system using keratin and integrated with MSC-derived exosomes and UK5099 promoted hair regrowth more efficiently than traditional delivery methods.

This study found that finasteride-loaded microspheres effectively treated androgenic alopecia in a mouse model, showing similar hair growth effects to orally-administered finasteride.

This study found that in vivo, a novel microneedle system for valproic acid delivery may improve hair regrowth efficacy by upregulating hair follicle development pathways more effectively than topical application.

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

This study investigates the potential hair growth effects of Panax ginseng and its ginsenosides on human hair follicles, suggesting mechanisms similar to those of minoxidil.

This review concluded that oral finasteride for men and topical minoxidil for both genders have the most evidence supporting their effectiveness and safety for treating androgenetic alopecia.

The researchers reported that DHT-inducible DKK-1 may play a significant role in DHT-driven balding by inhibiting hair follicle cell growth and promoting apoptosis in androgenetic alopecia.

This study found that dutasteride more effectively reduced serum dihydrotestosterone levels than finasteride in patients with benign prostatic hyperplasia.

This study found that in women undergoing chemotherapy after breast surgery, topical minoxidil significantly shortened the duration of hair loss compared to a placebo without significant side effects.

Minoxidil prolongs cell life, slows aging, and may produce longer hairs.