Facile Fabrication of Cedrol Nanoemulsions with Deep Transdermal Delivery Ability and High Safety for Effective Androgenic Alopecia Treatment

    September 2024 in “ Colloids and Surfaces B Biointerfaces
    Bin Chen, Liang Guo, Shaojun Wang, J. M. Xu, Honghong Han, Ruiyao Cui, Xiaofeng Ding, Guoqiang Cai, Ning Tan, Dawei Li, Jing Wang, Peng Cao
    TLDR Cedrol nanoemulsions effectively treat hair loss by promoting hair growth and reducing DHT levels safely.
    This study introduces cedrol nanoemulsions (CD-NEs) as a novel treatment for androgenic alopecia (AGA). Cedrol (CD) inhibits 5α-reductase 2 (5αR2) and promotes cell proliferation, similar to finasteride but with fewer side effects. CD-NEs enhance transdermal penetration by altering lipid organization, facilitating deeper skin delivery. In vivo tests on C57BL/6 mice show that CD-NEs significantly promote hair follicle regeneration and reduce dihydrotestosterone (DHT) levels in the skin. The findings suggest CD-NEs as a promising, safe, and effective treatment for AGA.
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