Cedrol-Loaded Dissolvable Microneedles Based on Flexible Backing for Promoting Hair Growth

August 2023 in “ Expert opinion on drug delivery ”

Yanjun Zhou, Luan Jia, Guangshuai Zhang, Gang Chen, Di Zhou, Xianbao Shi, Qiang Fu, Ning Li

cedrol dissolvable microneedles hair follicles polyvinylpyrrolidone K25 C57BL/6 mice hair growth PVP K25

TLDR Cedrol-loaded microneedles effectively promote hair growth.

The study developed dissolvable microneedles loaded with cedrol on a flexible backing to deliver the compound directly to the dermis, enhancing drug concentration in hair follicles. The microneedles, made with cedrol and polyvinylpyrrolidone K25, demonstrated good mechanical properties and efficient skin penetration in tests. Pharmacodynamical studies on C57BL/6 mice showed that these microneedles effectively promoted hair growth. The results suggest that cedrol-loaded dissolvable microneedles could be a promising treatment for hair loss.

View this study on tandfonline.com →

Discuss this study in the Community →

Cited in this study

17 / 17 results

research Duo-Role Platelet-Rich Plasma: Temperature-Induced Fibrin Gel and Growth Factors' Reservoir for Microneedles to Promote Hair Regrowth

February 2023 in “Journal of Advanced Research”

A new method using Platelet-rich Plasma (PRP) in a microneedle can promote hair regrowth more efficiently and is painless, minimally invasive, and affordable.

research CircAGK Regulates High Dihydrotestosterone-Induced Apoptosis in DPCs Through the miR-3180-5p/BAX Axis

1 citations , January 2023 in “The FASEB Journal”

CircAGK affects cell death in hair cells by controlling the miR-3180-5p/BAX pathway, which can lead to hair loss.

research Advances in Microneedles Research Based on Promoting Hair Regrowth

1 citations , January 2023 in “Journal of Controlled Release”

research Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia

1 citations , August 2022 in “Journal of Dermatological Treatment”

research Dual-Mode Vasodilator M119 Delivery to Hair Follicle via Dissolving Microneedle for Advanced Alopecia Treatment

2 citations , May 2022 in “Advanced therapeutics”

research Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model

12 citations , February 2022 in “Acta Biomaterialia”

Minoxidil-loaded hyaluronic acid microneedles can effectively increase hair growth and could be a promising treatment for hair loss.

research Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment

38 citations , July 2021 in “ACS Nano”

Microneedles help treat hair loss by improving hair surroundings and promoting growth.

research Hair Growth Promoting Activity of Cedrol Nanoemulsion in C57BL/6 Mice and Its Bioavailability

12 citations , March 2021 in “Molecules”

Cedrol Nanoemulsion was found to be more effective at promoting hair growth than traditional treatments and had better bioavailability.

research Autologous Activated Platelet-Rich Plasma (AA-PRP) and Non-Activated (A-PRP) in Hair Growth: A Retrospective, Blinded, Randomized Evaluation in Androgenetic Alopecia

44 citations , February 2020 in “Expert Opinion on Biological Therapy”

research Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia

41 citations , January 2020 in “BioMed Research International”

Micrografts improve hair density and thickness without side effects.

research Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia

33 citations , December 2019 in “Journal of Controlled Release”

Microneedles with enhancer effectively promote hair growth and increase hair density.

Cedrol-Loaded Dissolvable Microneedles Based on Flexible Backing for Promoting Hair Growth

Cited in this study

research Duo-Role Platelet-Rich Plasma: Temperature-Induced Fibrin Gel and Growth Factors' Reservoir for Microneedles to Promote Hair Regrowth

research CircAGK Regulates High Dihydrotestosterone-Induced Apoptosis in DPCs Through the miR-3180-5p/BAX Axis

research Advances in Microneedles Research Based on Promoting Hair Regrowth

research Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia

research Dual-Mode Vasodilator M119 Delivery to Hair Follicle via Dissolving Microneedle for Advanced Alopecia Treatment

research Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model

research Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment

research Hair Growth Promoting Activity of Cedrol Nanoemulsion in C57BL/6 Mice and Its Bioavailability

research Autologous Activated Platelet-Rich Plasma (AA-PRP) and Non-Activated (A-PRP) in Hair Growth: A Retrospective, Blinded, Randomized Evaluation in Androgenetic Alopecia

research Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia

research Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia

research Transcutaneous Implantation of Valproic Acid-Encapsulated Dissolving Microneedles Induces Hair Regrowth

research Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

research Hair Growth Promotion Effect of Cedrol Cream and Its Dermatopharmacokinetics

research Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation

research Hair Growth Promoting Activity of Cedrol Isolated from the Leaves of Platycladus Orientalis

research Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model