Evaluation of Antiarthritic and Antinociceptive Effects of Cedrol in a Rat Model of Arthritis

The study investigated the effects of cedrol, a natural sesquiterpene, on arthritis in a rat model induced by Complete Freund's Adjuvant (CFA). Cedrol, at doses of 10 mg/kg and 20 mg/kg, showed significant antiarthritic and antinociceptive effects by reducing arthritis scores, paw volume, and thermal hyperalgesia, especially at the higher dose. It also decreased proinflammatory cytokines IL-1β and TNF-α and improved oxidative stress markers by increasing SOD and GPx activities. These effects were comparable to indomethacin, a known anti-inflammatory drug. The study concluded that cedrol could be a promising therapeutic agent for rheumatoid arthritis due to its anti-inflammatory and antioxidant properties.