Injectable Polysaccharide-Based Hydrogel Delivering Poria Cocos Extracellular Vesicles Promotes Hair Regeneration in Androgenetic Alopecia via Wnt/β-Catenin Signaling

    May 2026 in “ International Journal of Biological Macromolecules ”
    Huiting Luo, Shang Wang, Hantao Wang … Dazhi Ke
    Studysummary In this study, researchers developed a biomacromolecular hydrogel to deliver plant-derived extracellular vesicles for treating androgenetic alopecia in a mouse model, which significantly improved hair regrowth and follicle density by activating Wnt/β-catenin signaling.
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    Research cited in this study 26

    1. Exosomes in Trichology: A Literature Review JPRAS Open · 2025
    2. Comparative Efficacy of Minoxidil and 5-Alpha Reductase Inhibitors Monotherapy for Male Pattern Hair Loss: Network Meta-Analysis Study of Current Empirical Evidence Journal of Cosmetic Dermatology · 2025
    3. Pathophysiological Mechanisms of Hair Follicle Regeneration and Potential Therapeutic Strategies Stem Cell Research & Therapy · 2025
    4. Microenvironment-Responsive Recombinant Collagen XVII-Based Composite Microneedles for the Treatment of Androgenetic Alopecia Acta Biomaterialia · 2025
    5. A Comprehensive Literature Review: The Potential of Exosomes in Hair Growth and Transplantation International Society of Hair Restoration Surgery · 2025
    6. Exosomes Derived From Mouse Vibrissa Dermal Papilla Cells Promote Hair Follicle Regeneration During Wound Healing By Activating Wnt/β-Catenin Signaling Pathway Journal of Nanobiotechnology · 2024
    7. Retinoic Acid Drives Hair Follicle Stem Cell Activation via Wnt/Beta-Catenin Signalling in Androgenetic Alopecia JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    8. Androgenetic Alopecia: An Update JAAD International · 2023
    9. Compliance to Topical Minoxidil and Reasons for Discontinuation Among Patients With Androgenetic Alopecia Dermatology and therapy · 2023
    10. Cellular Senescence: Ageing and Androgenetic Alopecia Dermatology · 2023
    11. The Stem Cell Quiescence and Niche Signaling Is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse Stem cell research & therapy · 2022
    12. The Psychological Consequences of Androgenetic Alopecia: A Systematic Review Journal of Cosmetic Dermatology · 2022
    13. Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model Acta Biomaterialia · 2022
    14. Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation Cells · 2022
    15. Alleviation of Androgenetic Alopecia with Aqueous Paeonia Lactiflora and Poria Cocos Extract Intake Through Suppressing the Steroid Hormone and Inflammatory Pathway Pharmaceuticals · 2021
    16. Health-Related Quality of Life, Depression, and Self-Esteem in Patients With Androgenetic Alopecia JAMA Dermatology · 2021
    17. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    18. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020
    19. Triterpenes in the Ethanol Extract of Poria Cocos Induce Dermal Papilla Cell Proliferation International Journal of Pharmacology · 2019
    20. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    21. The Inconsistent Regulation of HOXC13 on Different Keratins and the Regulation Mechanism on HOXC13 in Cashmere Goat (Capra Hircus) BMC Genomics · 2018
    22. The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target During Hair Follicle and Nail Differentiation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    23. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    24. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    25. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    26. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002