Multifunctional Hydrogel Based on Oxidized Sodium Alginate and Carboxymethyl Chitosan Delivers Minoxidil Loaded Liposomes for the Treatment of Androgenetic Alopecia

    Qian Du, XiaoShun Yao, Na Ni, Zixiong Wang, Na Liu, Le Kang, M Chen, Langqun Tan, Dequn Wu, Xiaofeng Ding, Yongxian Lai
    TLDR The hydrogel improves hair growth treatment by enhancing drug delivery and promoting follicle repair.
    The study developed a nanofiber-enhanced hydrogel containing minoxidil-loaded liposomes to treat androgenetic alopecia (AGA). This hydrogel addresses minoxidil's poor solubility by using liposomes to enhance drug delivery and therapeutic efficacy. The hydrogel, made from oxidized sodium alginate and carboxymethyl chitosan, features dynamic covalent bonding for good injectability and self-repairing qualities. It can be applied to the skin to release the drug gradually and continuously. Additionally, the hydrogel incorporates antimicrobial and antioxidant properties through quaternary ammonium salts and tea polyphenols, aiming to enhance therapeutic efficacy, promote follicular repair, and accelerate hair growth. This multifunctional platform offers a promising integrated therapy for AGA by combining drug delivery with antimicrobial and antioxidant strategies.
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