Optimizing Efficacy: Hyaluronic Acid Liposomes Encapsulating Minoxidil for Enhanced Transdermal Delivery and Treatment of Androgenetic Alopecia

July 2025 in “ Colloids and Surfaces B Biointerfaces ”

Ziyi Zhao, Yue Wang, Hui Xing, Yucheng Wang, Kai Lv, Xiangjun Pan, Tuo Chen, Yunfeng Hu, Guowei Li, Dong Ma

minoxidil hyaluronic acid liposomes androgenetic alopecia transdermal delivery angiogenesis inflammation-related genes hair follicle microenvironment Rogaine

TLDR A new method using hyaluronic acid liposomes improves Minoxidil's effectiveness and safety for hair growth treatment.

The study presents a novel transdermal delivery system, HL@Mi, which encapsulates Minoxidil (Mi) in hyaluronic acid liposomes to enhance its efficacy in treating androgenetic alopecia (AGA). This system improves Mi's skin penetration and retention, reduces cytotoxicity, and optimizes the hair follicle microenvironment by promoting angiogenesis and regulating inflammation-related genes. In an AGA animal model, HL@Mi effectively downregulated inflammatory factors and promoted hair growth, demonstrating good biocompatibility and safety. This innovative approach offers a more efficient and safer alternative for Mi delivery, with potential applications in other local drug delivery strategies.

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