The Efficacy and Safety of Ablative Fractional CO2 Laser Combined With Topical Minoxidil for Male Androgenetic Alopecia: A Randomized Clinical Trial

    January 2026 in “ Dermatologic Therapy ”
    Xu Zhao, Lin Peng, Fanjun Xu … Miao Jiang
    Studysummary This study found that combining ablative fractional CO2 laser treatment with topical minoxidil significantly improved frontal hairline regrowth and patient satisfaction in men with androgenetic alopecia compared to using minoxidil alone, without serious adverse effects.
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    Research cited in this study 34

    1. Nonablative Er:YAG Laser Treatment of Androgenetic Alopecia: A Clinical Observation Dermatologic Therapy · 2025
    2. Accelerated Aging of Hair Follicles in Androgenetic Alopecia British journal of dermatology/British journal of dermatology, Supplement · 2024
    3. Trichoscopy of Androgenetic Alopecia: A Systematic Review Journal of clinical medicine · 2024
    4. Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia Medicine · 2023
    5. Androgenetic Alopecia: Therapy Update Drugs · 2023
    6. Fractional Carbon Dioxide Laser Alone and as an Assisted Drug Delivery for Treatment of Alopecia Areata: A Clinical, Dermoscopic and Immunohistochemical Study Archives of Dermatological Research · 2023
    7. Evaluation of Anxiety and Depression in Patients with Androgenetic Alopecia in Shanghai: A Cross-Sectional Study Dermatologic Therapy · 2023
    8. Comparative Study Between Topical Application of Triamcinolone Acetonide After Fractional Carbon Dioxide Laser Versus Microneedling in the Treatment of Resistant Alopecia Areata Dermatologic Therapy · 2022
    9. Ablative 2940 Nm Er: YAG Fractional Laser for Male Androgenetic Alopecia Dermatologic Therapy · 2022
    10. Comparative Study Between Topical Methotrexate 1% Gel and Minoxidil 5% Gel in the Treatment of Localized Alopecia Areata Dermatologic Therapy · 2022
    11. The Psychological Consequences of Androgenetic Alopecia: A Systematic Review Journal of Cosmetic Dermatology · 2022
    12. Relative Efficacy of Minoxidil and the 5-Alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients JAMA Dermatology · 2022
    13. The Comparison of Trichoscopic Findings in Female Pattern Hair Loss and Chronic Telogen Effluvium in Female Patients Journal of pharmaceutical research international · 2021
    14. Lessons Learned from the First Decade of Laser-Assisted Drug Delivery Dermatology and Therapy · 2021
    15. Fractional-Assisted Drug Delivery Performed with Erbium YAG Laser in Androgenic Alopecia: Histological Aspects Dermatologic Therapy · 2021
    16. Trichoscopic Findings in Androgenetic Alopecia Medicinski arhiv · 2021
    17. Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians Fertility and Sterility · 2020
    18. Hair Distribution Width – A Novel Trichoscopy Parameter for Hair Miniaturization in Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2019
    19. Laser-Assisted Hair Regrowth Plastic and reconstructive surgery. Global open · 2019
    20. Effects of CO2 Fractional Laser on Hair Growth in C57BL/6 Mice and Potential Underlying Mechanisms Chinese Medical Journal · 2019
    21. Types of Hairline Recession in Androgenetic Alopecia and Perceptions of Aging in Asian Males International Journal of Dermatology · 2019
    22. The Effect of the Fractional Carbon Dioxide Laser on Improving Minoxidil Delivery for the Treatment of Androgenetic Alopecia Journal of lasers in medical sciences · 2019
    23. White And Yellow Dots As New Trichoscopic Signs Of Severe Female Androgenetic Alopecia In Dark Skin Phototypes International Journal of Dermatology · 2018
    24. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version Journal of The European Academy of Dermatology and Venereology · 2017
    25. Enhancing Hair Growth in Male Androgenetic Alopecia by a Combination of Fractional CO2 Laser Therapy and Hair Growth Factors Lasers in Medical Science · 2017
    26. Hair Regrowth Through Wound Healing Process After Ablative Fractional Laser Treatment in a Murine Model Lasers in Surgery and Medicine · 2015
    27. Similar Response Patterns to Topical Minoxidil Foam 5% in Frontal and Vertex Scalp of Men with Androgenetic Alopecia: A Microarray Analysis British Journal of Dermatology · 2014
    28. Scalp Dermatoscopic Findings in Androgenetic Alopecia and Their Relations with Disease Severity Annals of Dermatology · 2014
    29. Analysis of Familial Factors Using the Basic and Specific (BASP) Classification in Korean Patients with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2011
    30. Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities British Journal of Dermatology · 2010
    31. Prevalence and Types of Androgenetic Alopecia in Shanghai, China: A Community-Based Study British Journal of Dermatology · 2009
    32. Scalp Dermoscopy of Androgenetic Alopecia in Asian People Journal of Dermatology · 2009
    33. A New Classification of Pattern Hair Loss That Is Universal for Men and Women: Basic and Specific (BASP) Classification Journal of The American Academy of Dermatology · 2007
    34. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002