Accelerated Aging of Hair Follicles in Androgenetic Alopecia

May 2024 in “ British journal of dermatology/British journal of dermatology, Supplement ”

Summik Limbu, Kim Farhat, Leah Redmond, Nilofer Farjo, Bessam Farjo, Paul Kemp, Claire A. Higgins

androgenetic alopecia hair follicles methylation dermal papilla TRPS1 EGR1 vellus-type hair AGA DP

TLDR Hair follicles in androgenetic alopecia age faster, especially in the front.

The study investigated whether hair follicles in androgenetic alopecia (AGA) exhibit accelerated aging by comparing the methylation levels of genes associated with aging in frontal and occipital follicles. The biological age of the follicles was assessed using methylation status of specific genes (n = 3), and microarray analysis was conducted on dermal papilla (DP) from both regions (n = 4). Results showed that frontal follicles have a significantly higher biological age than occipital follicles, indicating accelerated aging in AGA. Transcriptomic analysis revealed increased expression of aging-related genes in frontal DP, and decreased expression of TRPS1, a gene that represses EGR1 and is associated with vellus-type hair. The findings suggest that accelerated aging in frontal follicles may be driven by changes in TRPS1 regulation.

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