Fractional Carbon Dioxide Laser Alone and as an Assisted Drug Delivery for Treatment of Alopecia Areata: A Clinical, Dermoscopic and Immunohistochemical Study

February 2023 in “ Archives of Dermatological Research ”

Azza Mahfouz Abdel Meguid, Alaa Ghazally, Abdel Ghaffar M. Ahmed, Radwa M Bakr

fractional carbon dioxide laser alopecia areata Triamcinolone acetonide platelet-rich plasma vitamin D anagen follicles telogen follicles catagen follicles Decorin FCL AA TA PRP

From the encyclopedia

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Triamcinolone Acetonide →

Platelet-Rich Plasma →

growth factors taken from your blood and injected into your scalp to stimulate hair

Studysummary This study found fractional carbon dioxide laser therapy effective in treating alopecia areata, both alone and with topical treatments, suggesting decorin's involvement in improving hair growth. Our plain-language summary of this paper — not a Tressless recommendation.

The study involved 64 patients with alopecia areata (AA) and examined the effectiveness of fractional carbon dioxide laser (FCL) treatment alone and in combination with Triamcinolone acetonide (TA), platelet-rich plasma (PRP), and vitamin D. All treatment groups showed significant improvement, with the best response observed in the group treated with FCL and TA (72.6% improvement), and the least improvement in the group treated with FCL alone (57.5% improvement). Histologic examination revealed an increase in the number of anagen follicles and a decrease in the number of telogen/catagen follicles after treatment. The study also found a significant increase in the expression of Decorin, a protein involved in hair growth, after treatment. The study concluded that FCL, both alone and in combination with other treatments, is effective in treating AA, and that the upregulation of decorin expression is associated with restoration of hair growth in AA.

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31 / 31 results

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