Efficacy and Safety of Ablative Fractional CO2 Laser Therapy for Localized Scleroderma: A Comprehensive Bench-to-Bedside Approach

    January 2025 in “ Dermatologic Therapy ”
    Ke Chai, Zehong Song, Bingsi Tang … Rong Xiao
    Studysummary This study found that ablative fractional carbon dioxide laser treatment improved skin fibrosis, reduced skin hardening, and enhanced hair follicle growth in localized scleroderma patients, with significant improvements across several clinical measures and no severe adverse effects observed.
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    Research cited in this study 9

    1. Exosomes Derived From Mouse Vibrissa Dermal Papilla Cells Promote Hair Follicle Regeneration During Wound Healing By Activating Wnt/β-Catenin Signaling Pathway Journal of Nanobiotechnology · 2024
    2. A Comparative Study of Fractional CO2 Laser with Topical Triamcinolone Acetonide Versus Intralesional Triamcinolone Acetonide in the Treatment of Alopecia Areata Journal of Cutaneous and Aesthetic Surgery · 2024
    3. The Use of a 1,540 nm Fractional Erbium-Glass Laser in the Treatment of Alopecia Areata Lasers in surgery and medicine · 2019
    4. Mechanical Stretch Induces Hair Regeneration Through the Alternative Activation of Macrophages Nature Communications · 2019
    5. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    6. Hair Regrowth Through Wound Healing Process After Ablative Fractional Laser Treatment in a Murine Model Lasers in Surgery and Medicine · 2015
    7. Involvement of Mechanical Stress in Androgenetic Alopecia International Journal of Trichology · 2015
    8. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    9. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007