A Combination Therapy for Androgenic Alopecia Based on Quercetin and Zinc/Copper Dual-Doped Mesoporous Silica Nanocomposite Microneedle Patch

    December 2022 in “ Bioactive Materials ”
    Zhaowenbin Zhang, Wenbo Li, Di Chang, Zi-Qin Wei, Endian Wang, Jing Yu, Yuze Xu, Yumei Que, Yan-Xin Chen, Chen Fan, Bing Ma, Yanling Zhou, Zhiguang Huan, Chen Yang, Feng Guo, Chen Yang
    TLDR The microneedle patch with quercetin, zinc, and copper effectively promotes hair regrowth for androgenic alopecia.
    Researchers developed a microneedle patch (ZCQ/MN) containing quercetin, zinc, and copper to treat androgenic alopecia (AGA). The patch dissolves in the skin, releasing these active ingredients to promote hair follicle regeneration by inhibiting dihydrotestosterone, reducing inflammation, promoting angiogenesis, and activating hair follicle stem cells. Tested on 8-week-old C57BL/6 mice (n=6 per group), the ZCQ/MN group showed significant hair regrowth, achieving 95.33% hair coverage by day 14. In vitro experiments on human hair follicle dermal papilla cells confirmed the combination's efficacy in enhancing cell proliferation and protection against dihydrotestosterone-induced injury. The study concludes that ZCQ/MN is a promising, biocompatible treatment for AGA, offering better efficacy than current treatments like minoxidil.
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