New Plant Extracts Exert Complementary Anti-Hair Loss Properties in Human In Vitro and Ex Vivo Models

November 2024 in “ Journal of Cosmetic Dermatology ”

Daniel Bacqueville, Marguerite Lévêque, Camille Mas, Marie‐José Haure, Anaïs Noustens, V. Mengeaud, Sophie Carrère, S. Bessou‐Touya, Jimmy Le Digabel, Nicoletta Rizzi, Jean‐Hilaire Saurat

Silybum marianum extract Lespedeza capitata extract manganese salt of L-pyrrolidone carboxylic acid EGFR PDGFR Wnt/β-catenin pathway versican VEGF DHT androgen metabolism anagen phase milk thistle MnPCA vascular endothelial growth factor dihydrotestosterone

Studysummary This study observed that a topical serum containing Silybum marianum extract, manganese PCA, and Lespedeza capitata extract enhanced hair follicle growth and hair shaft elongation, while prolonging the anagen phase in an ex vivo human scalp skin model, suggesting potential benefits for hair loss treatment.

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