Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways
May 2024
in “
Archives of dermatological research
”
Enz_MoriL Morus alba L. Wnt/β-Catenin JAK-STAT human dermal papilla cells hDPCs anagen phase catagen phase β-catenin GSK3β DKK-1 Wnt family members 3a Wnt family members 5a Wnt family members 7a JAK1 STAT3 interferon-gamma IFN-γ alopecia areata white mulberry Wnt signaling JAK-STAT signaling hair growth phase hair loss phase beta-catenin glycogen synthase kinase 3 beta dickkopf-related protein 1 Wnt3a Wnt5a Wnt7a Janus kinase 1 signal transducer and activator of transcription 3 IFN-gamma autoimmune hair loss
Studysummary This study found that Enz_MoriL, a compound derived from Morus alba L., promotes hair follicle cell proliferation by affecting the Wnt/β-catenin pathway and can counteract an alopecia areata-like condition by suppressing the JAK-STAT signaling in human hair follicle dermal papilla cells.
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