Moracin M Promotes Hair Regeneration Through Activation of the WNT/β-Catenin Pathway and Angiogenesis

The study explores the effects of Moracin M, a compound from the Moraceae family, on hair growth and vascular regeneration. Moracin M significantly increases cell proliferation in human dermal papilla cells and promotes cell migration in human umbilical vein endothelial cells without cytotoxicity at concentrations up to 50 µM. It activates the WNT/β-catenin pathway, enhancing Wnt signaling and upregulating transcription factors, leading to increased levels of growth factors such as VEGF, FGF2, KGF, HGF, and MYC. These effects are comparable to minoxidil, an FDA-approved treatment. Moracin M also increases protein and mRNA levels of VEGF, FGF2, and KGF under inflammatory conditions and reduces wound width in a dose-dependent manner. The findings suggest that Moracin M enhances hair growth through cell proliferation and angiogenesis, making it a promising alternative to existing treatments. Further research is needed to fully understand its mechanisms and efficacy.