January 202057
Adding topical minoxidil 5% to oral finasteride raised a hair growth index from 30% to 60% by initiating anagen. One PRP trial found hair density rose 12.8% over baseline. Another PRP trial found injections alone did not improve growth, and microneedling alone matched microneedling plus PRP. Scalp micrografts increased density by 23 hairs/cm². Botulinum toxin A injections were measured for effectiveness and safety. Oral dutasteride raised hair count more than intralesional injection, though route comparison was unreliable. Saw palmetto supplements showed modest benefit with limited high-quality evidence. Exosome therapy was reported to promote hair growth, though clinical trials were lacking. PRP with microneedling and concentrated growth factor was reported to reduce shedding and raise hair count. Combining beard and body hair grafts improved visual density in advanced baldness. Spanish dermatologists' prescriptions of oral dutasteride and oral minoxidil rose sharply since 2017.
- Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study In a small placebo-controlled trial, PRP raised hair density 12.8% over baseline in AGA, with response correlating with GDNF concentration.
- Placebo‐controlled dose‐effect studies with topical minoxidil 2% or 5% in male‐patterned hair loss treated with oral finasteride employing an analytical and exhaustive study protocol In a small trial, adding topical minoxidil 5% to oral finasteride raised a hair growth index from 30% to 60% by initiating anagen, without converting miniaturized follicles.
- Oral Minoxidil: A Possible New Therapy for Androgenetic Alopecia oral minoxidil is discussed as a possible new therapy for androgenetic alopecia.
- Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia In a placebo-controlled trial, scalp micrografts increased hair density by 23 hairs/cm² at 58 weeks in androgenetic alopecia.
- Finasteride Counseling for Male Androgenetic Alopecia Should Reflect Updated Findings on Prostate Cancer Risk Finasteride counseling for male pattern hair loss should reflect updated findings on prostate cancer risk.
- Exosomes: A New Effective Non-Surgical Therapy for Androgenetic Alopecia? Exosome therapy shows promise for hair growth with no reported adverse events, but clinical trials are lacking.
- Low-Dose Oral Minoxidil for Female Pattern Hair Loss: A Unicenter Descriptive Study of 148 Women a single-center descriptive study of low-dose oral minoxidil in 148 women with female pattern hair loss.
- Platelet-rich Plasma for Androgenetic Alopecia Treatment: A Randomized Placebo-controlled Pilot Study In a randomized placebo-controlled trial of 30 men, PRP injections alone did not improve hair growth in androgenetic alopecia.
- Effectiveness and Safety of Botulinum Toxin Type A in the Treatment of Androgenetic Alopecia placeholder
- Natural Hair Supplement: Friend or Foe? Saw Palmetto, a Systematic Review in Alopecia A systematic review found saw palmetto supplements showed modest hair benefits and good tolerability, but high-quality evidence is lacking.
- Efficacy of Intralesional and Oral Dutasteride in the Treatment of Androgenetic Alopecia: A Systematic Review A systematic review found oral dutasteride raised hair count more than intralesional injection, but data are insufficient to compare the routes reliably.
- Dermoscopic assessment of microneedling alone versus microneedling with platelet-rich plasma in cases of male pattern alopecia: A split-head comparative study In a 30-patient split-scalp study, microneedling alone improved hair measures as much as microneedling plus PRP, with no added PRP benefit.
- Jagged1 and Epidermal Growth Factor Promoted Androgen-Suppressed Mouse Hair Growth In Vitro and In Vivo In mice with testosterone-suppressed hair growth, combined topical Jagged1 and EGF promoted hair regrowth; neither alone did.
- Androgenetic alopecia is associated with increased scalp hardness Androgenetic alopecia is associated with increased scalp hardness.
- Significant relationship between temporal hair loss and other scalp areas in female pattern hair loss In 109 women with pattern hair loss, temporal thinning was common and correlated with other scalp areas; authors urge adding it to classification.
- Impact of the Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma (A-PRP) and Activated Platelet-Rich Plasma (AA-PRP) in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation A review of eight PRP kits found closed-technique methods meeting consensus quality criteria yield reproducible non-activated PRP.
- Commentary on: Platelet-Rich Plasma and Stem Cells for Hair Growth: A Review of the Literature Commentary on literature review of PRP and stem cells for hair growth, noting relapse after 12 months supports maintenance injections.
- Clinical Efficacy of a Topical Compounded Formulation in Male Androgenetic Alopecia: Minoxidil 10%, Finasteride 0.1%, Biotin 0.2%, and Caffeine Citrate 0.05% Hydroalcoholic Solution. Five men using a compounded topical (minoxidil 10%, finasteride 0.1%, biotin, caffeine) showed moderate hair improvement over 6 months.
- Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review A review argues topical caffeine, which penetrates skin easily, may offer a well-tolerated alternative treatment for androgenetic alopecia.
- Co-loading of finasteride and baicalin in phospholipid vesicles tailored for the treatment of hair disorders Finasteride-and-baicalin-loaded phospholipid vesicles stimulated dermal papilla cells and improved hair growth in mice.
- “Combination grafting” of scalp and body hair to enhance the visual density of hair transplant and coverage of higher grade of baldness In 16 patients with advanced baldness, combining beard and body hair with scalp grafts improved visual density and coverage.
- Histopathological Findings of Uncomplicated Hair Transplant for Male Androgenetic Alopecia: Can Lichen Planopilaris Features Be Present? Post-transplant scalp biopsies in 8 AGA patients showed lymphocytic infiltrate and fibrosis mimicking lichen planopilaris.
- Azelaic acid stimulates catalase activation and promotes hair growth through upregulation of Gli1 and Gli2 mRNA and Shh protein. Azelaic acid protected hair follicle cells from UVB damage and may enhance minoxidil effects via Shh protein in organ culture.
- Prescribing Habits for Androgenic Alopecia among Dermatologists in Spain in 2019–2020: A Cross-Sectional Study A survey of 243 Spanish dermatologists found oral dutasteride and oral minoxidil prescriptions for pattern hair loss rose sharply since 2017.
- Efficacy of platelet-rich plasma and concentrated growth factor in treating androgenetic alopecia – A retrospective study A retrospective study reported PRP with microneedling and concentrated growth factor reduced shedding and significantly raised hair count over six months.
- The Alopecia Areata Investigator Global Assessment scale: a measure for evaluating clinically meaningful success in clinical trials Interviews with clinicians and patients developed the AA-IGA scale, defining treatment success as regrowth to ≤20% scalp-hair loss.
- A “hair‐raising” history of alopecia areata A historical review tracing alopecia areata treatments from ancient Egypt to modern genetics and immunology.
- Topical niacinamide does not stimulate hair growth based on the existing body of evidence Niacinamide failed to stimulate VEGF synthesis in vitro, suggesting it does not promote hair growth.
- Patch testing and contact allergen avoidance in patients with lichen planopilaris and/or frontal fibrosing alopecia: A cohort study a cohort study of patch testing and allergen avoidance in lichen planopilaris and frontal fibrosing alopecia.
- New insights into human hair: SAXS, SEM, TEM and EDX for Alopecia Areata investigations Lab imaging showed alopecia areata regrown white hair has surface defects, empty vesicles and altered melanin versus healthy hair.
- Efficacy and Influence Factors of 308‐nm Excimer Lamp with Minoxidil in the Treatment of Alopecia Areata Adding 308-nm excimer lamp to minoxidil significantly increased hair number and diameter in alopecia areata lesions, with tolerable redness and pigmentation.
- [XANTHOTRICHIA (YELLOWING OF THE HAIR) DUE TO MINOXIDIL TREATMENT]. a patient developed yellowing of the hair attributed to topical minoxidil, with discussion of drug-induced hair colour changes.
- [JAK INHIBITORS FOR THE TREATMENT OF ALOPECIA AREATA]. review of JAK inhibitors for alopecia areata.
- Formononetin: Novel Deal for Androgenetic Alopecia Formononetin proposed as novel treatment for androgenetic alopecia.
- Expression of CD117 and platelet-derived growth factor receptor α in patients with alopecia areata CD117 expression differed and PDGFRα correlated with severity in 30 AA patients versus 18 controls.
- The impact of oxidative stress in the androgenic alopecia in women examines oxidative stress impact in female androgenic alopecia.
- Effect of Behavioral Factors on Severity of Female Pattern Hair Loss: An Ordinal Logistic Regression Analysis In 1,825 Chinese women with FPHL, age, poor sleep, alcohol, ponytail hairstyles, and oily scalp were associated with more severe hair loss.
- YKL-40 a sensitive biomarker for early androgenetic alopecia and early hidden metabolic syndrome Serum YKL-40 was elevated in early-onset AGA and associated with metabolic syndrome in 100 patients and controls.
- Serum ferritin and vitamin D levels should be evaluated in patients with diffuse hair loss prior to treatment Patients with diffuse hair loss had lower ferritin and vitamin D than controls; authors recommend checking both before treatment.
- Vitamin D Receptor gene polymorphisms taq-1 and cdx-1 in female pattern hair loss In a small case-control study, vitamin D receptor Taq-1 and Cdx-1 gene variants were more common in female pattern hair loss, raising risk severalfold.
- Frontal fibrosing alopecia: a disease that remains enigmatic A review of frontal fibrosing alopecia's clinical patterns, unknown aetiology and proposed treatments.
- Prognostic Factors in Mexican Patients with Patchy and Other Types of Alopecia Areata In 104 Mexican AA patients, body hair involvement predicted progression while treatment adherence predicted remission.
- Modifications of Multi Slit Knife for enhanced versatility in balding and vertex area hair transplant A modified Multi Slit Knife creates recipient sites faster with less damage to existing hairs and better vertex whorl adaptation.
- Female androgenetic alopecia with male pattern caused by an androgen-producing tumor Two women with male-pattern hair loss had ovarian androgen-secreting tumors; hair loss resolved after tumor removal.
- Efficacy and Tolerability of a Shampoo Containing Broad-Spectrum Cannabidiol in the Treatment of Scalp Inflammation in Patients with Mild to Moderate Scalp Psoriasis or Seborrheic Dermatitis A cannabidiol shampoo significantly reduced scalp inflammation, itching and scaling within two weeks in 50 patients with psoriasis or seborrheic dermatitis.
- A comparative study of therapeutic response to intralesional injections of platelet-rich plasma versus triamcinolone acetonide in alopecia areata In a 40-patient alopecia areata trial, PRP and triamcinolone injections gave similar regrowth, with PRP a safe steroid-sparing alternative.
- Platelet-rich plasma in alopecia areata: intradermal injection versus topical application with transepidermal delivery via either fractional carbon dioxide laser or microneedling In 60 alopecia areata patients, topical PRP after fractional CO2 laser or microneedling matched injected PRP efficacy with much less pain.
- The assessment of hair transplantation outcomes in cicatricial alopecia In 50 patients with cicatricial alopecia, hair transplantation gave good-to-excellent outcomes in 82%.
- Improvement of cell proliferation and antioxidant activity of silymarin in hair follicles dermal papillae isolated from the human scalp: Comparison with vitamin C effects In cultured human dermal papilla cells, silymarin and vitamin C increased proliferation and antioxidant capacity, vitamin C more strongly.
- More is not always better in hair growth factors. epidermal growth factor: hair growth factor involved in alopecia areata pathogenesis Serum EGF was higher in alopecia areata patients than controls and rose with severity, suggesting a role in disease pathogenesis.
- A Matched Case-Control Study of Zinc Levels in Androgenetic Alopecia and Alopecia Areata: Is There a Need to Do Routine Screening? Matched case-control study examines zinc levels in androgenetic alopecia and alopecia areata.
- Serum level of interleukin-15 in active alopecia areata patients and its relation to age, sex, and disease severity Serum IL-15 was elevated in active alopecia areata and correlated with disease severity.
- Analysis of Microscopic Examination of Pulled Out Hair in Telogen Effluvium Patients Microscopy of pulled hairs showed telogen effluvium patients have more atypical club hairs with remnant sheaths than healthy people.
- The role of family history and its influence on the onset time in female pattern hair loss Positive family history, especially maternal, was associated with female pattern hair loss and earlier onset in 240 Polish women.
- Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review
- Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells
- Examining the Safety and Efficacy of Low-Level Laser Therapy for Male and Female Pattern Hair Loss: A Review of the Literature