April 202049
Microneedling with minoxidil was reported to improve response by upregulating follicular sulfotransferase enzymes. Topical finasteride in postmenopausal women improved pattern hair loss more than 17α-estradiol, both with minoxidil. Bicarbonate-buffered local anesthetic reduced injection pain during hair transplantation. Cold Ringer's graft storage kept follicles alive through eight-hour megasessions in lab testing. A network meta-analysis ranked PRP, laser therapy and dutasteride above finasteride and minoxidil, though evidence quality was low. A PRP systematic review found most trials reported positive effects, and a PRP review found increased growth and thickness in nonscarring alopecia. A 5-alpha reductase inhibitor review concluded dutasteride is more potent than finasteride with comparable safety. Optimal transplant density was proposed at about 55 hairs/cm2 for Chinese patients.
- Microneedling improves minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes. Microneedling improved minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes.
- Theoretical basis and clinical practice for FUE megasession hair transplantation in the treatment of large area androgenic alopecia In lab testing with clinical confirmation, storing grafts in 4°C Ringer's solution kept hair follicles alive through 8-hour megasession FUE procedures.
- Efficacy of Topical Finasteride 0.5% vs 17α-Estradiol 0.05% in the Treatment of Postmenopausal Female Pattern Hair Loss: A Retrospective, Single-Blind Study of 119 Patients In 119 postmenopausal women, topical finasteride 0.5% plus minoxidil improved female pattern hair loss significantly more than 17α-estradiol plus minoxidil at 6 and 12-18 months.
- Pain perception of a new Ahmad‐Humayun solution for local anesthesia in hair transplantation: One step ahead In a 25-patient split-scalp study, adding bicarbonate buffer to hair-transplant local anesthetic significantly reduced injection pain (3.28 vs 4.96).
- Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil®, Finasteride®, and Adult Stem Cell-Based Therapy A systematic review of 12 trials found 84% reported positive PRP effects for androgenetic alopecia without major side effects, suggesting a safe alternative to minoxidil and finasteride.
- 5‐Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety A review concludes dutasteride is more potent than finasteride for androgenetic alopecia with a comparable safety profile on fertility, teratogenicity, neurotoxicity and hepatotoxicity.
- Efficacy of non-surgical treatments for androgenetic alopecia in men and women: a systematic review with network meta-analyses, and an assessment of evidence quality A network meta-analysis ranked PRP, laser therapy and dutasteride above finasteride and minoxidil for men, though evidence quality for top-ranked treatments was low.
- MR Imaging of Hair and Scalp for the Evaluation of Androgenetic Alopecia In 27 volunteers, scalp MRI distinguished alopecia from normal scalps and matched clinical severity staging in 96% of cases.
- Physiology and Medical Treatments for Alopecia A review of pattern hair loss biology noting minoxidil, finasteride and laser therapy remain the only FDA-approved medical treatments.
- Follicular Unit Excision A review of follicular unit excision noting scarless donor harvesting and graft transection rates under 4% with advanced devices.
- Robotic Hair Transplantation A review finds robotic hair transplantation offers precise, minimally invasive follicular extraction but cannot replace candidate selection and surgical judgment.
- Hair Loss and Hair Restoration in Women A review of evaluating and treating female hair loss, stressing workup for causes, biopsy for scarring alopecia, and managing post-transplant shock loss.
- Complications with Hair Transplantation A review of hair transplant complications, stating most are preventable with good planning, technique and patient adherence to aftercare.
- Efficacy of Postbiotics in a PRP-Like Cosmetic Product for the Treatment of Alopecia Area Celsi: A Randomized Double-Blinded Parallel-Group Study In a 160-patient randomized trial, a PRP-mimicking postbiotic product improved SALT scores by ~70% in alopecia areata versus no change with placebo.
- Serum 25 hydroxyvitamin D levels in alopecia areata, female pattern hair loss, and male androgenetic alopecia in a Chinese population In a large Chinese case-control study, vitamin D levels were significantly lower in alopecia areata, female pattern hair loss, and male androgenetic alopecia patients.
- New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP<sub>3</sub>‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75<sup>NTR</sup>and TrkA) in<i>ex vivo</i>human male androgenetic scalp hair follicles In ex vivo human AGA follicles, stress hormone CRH triggered catagen-promoting changes that caffeine significantly counteracted.
- Stratifying clinical response to adjuvant platelet‐rich plasma in patients with androgenetic alopecia A retrospective review asked whether response to adjuvant PRP in androgenetic alopecia can be predicted from hair counts after two sessions.
- Investigation of optimum transplant and extraction density based on the data from the donor area of Chinese androgenetic alopecia patients: a multicenter, retrospective study A multicenter study of 119 Chinese men proposed optimal transplant density of about 55 hairs/cm2 and minimum donor density of 106.88 hairs/cm2 for hair transplantation.
- Macrophage-Derived Extracellular Vesicle Promotes Hair Growth In mice and human follicles, macrophage-derived vesicles carrying Wnt proteins activated β-catenin signaling and promoted hair growth and shaft size.
- Review of the Use of Platelet-Rich Plasma in the Treatment of Alopecia A review finding evidence that PRP increases hair growth and thickness in nonscarring alopecia, with scarring alopecia data still limited.
- Predictive Metagenomic Profiling, Urine Metabolomics, and Human Marker Gene Expression as an Integrated Approach to Study Alopecia Areata Alopecia areata patients showed distinct scalp microbiome, gene expression, and urine metabolite profiles versus healthy controls.
- Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling Peptide Scaffold A 3D peptide scaffold restored hair-inductive markers in cultured human dermal papilla cells.
- A comprehensive review of biochemical factors in herbs and their constituent compounds in experimental studies on alopecia A review of experimental studies found herbal compounds act on the hair cycle, keratinocyte growth and inflammation, mostly in mice and cell models.
- Microskin‐Inspired Injectable MSC‐Laden Hydrogels for Scarless Wound Healing with Hair Follicles MSC-laden silk hydrogels healed wounds faster and scarlessly with hair follicles in preclinical models.
- Efficacy and Safety of Topical Calcipotriol 0.005% Versus Topical Clobetasol 0.05% in the Management of Alopecia Areata: An Intrasubject Pilot Study Topical calcipotriol showed faster but not significantly better regrowth than clobetasol in 35 alopecia areata patients.
- Deficiency of Crif1 in hair follicle stem cells retards hair growth cycle in adult mice Deleting mitochondrial protein Crif1 in mouse hair follicle stem cells retarded the hair growth cycle.
- LncRNA-PCAT1 maintains characteristics of dermal papilla cells and promotes hair follicle regeneration by regulating miR-329/Wnt10b axis In cultured dermal papilla cells and mice, lncRNA PCAT1 promoted hair follicle regeneration via the miR-329/Wnt10b axis.
- The effect of intradermal botulinum toxin on androgenetic alopecia and its possible mechanism A study examined intradermal botulinum toxin's effect on androgenetic alopecia and its possible mechanism.
- New and Emerging Therapies for Alopecia Areata A review covers emerging alopecia areata treatments, with JAK inhibitors leading ongoing clinical trials.
- Shared medical appointments for female pattern hair loss describes shared medical appointments as a care format for female pattern hair loss.
- Pattern hair loss: Assessment of microinflammation in miniaturized and terminal hair follicles through horizontal histologic sections a histologic assessment of microinflammation in miniaturized versus terminal follicles in pattern hair loss.
- Bicalutamide: A potential new oral antiandrogenic drug for female pattern hair loss Bicalutamide is proposed as a potential new oral antiandrogen for female pattern hair loss.
- 5α-Reductase inhibitors in men aged 50 years or older with androgenetic alopecia: A retrospective study a retrospective study of 5α-reductase inhibitor use in men aged 50 and older with pattern hair loss.
- Follicular Unit Transplantation A review of follicular unit transplantation strip technique, offering natural results with minimal downtime.
- Hair Transplantation for Scarring Alopecia A review describes evidence-based practices and challenges of hair transplantation in scarring alopecia.
- Techniques for Hair Restoration an overview of hair restoration techniques.
- Hair Transplantation: Advances in Diagnostics, Artistry, and Surgical Techniques an overview of advances in hair transplantation diagnostics, artistry, and surgical techniques.
- Reconstructed human skin shows epidermal invagination towards integrated neopapillae indicating early hair follicle formation in vitro In a lab skin model, dermal papilla spheroids induced epidermal invagination, a first step toward hair follicle formation in vitro.
- Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway Pantothenic acid promoted mink dermal papilla cell proliferation via ID3/Notch signaling in vitro.
- Hyperuricemia is associated with androgenetic alopecia in men: A cross‐sectional case‐control study A case-control study found men with early androgenetic alopecia had higher uric acid and more hyperuricemia than controls.
- Oral minoxidil improves background hair thickness in lichen planopilaris oral minoxidil improved background hair thickness in lichen planopilaris, a scarring alopecia.
- Study on the chemical constituents of nut oil from Prunus mira Koehne and the mechanism of promoting hair growth Nut oil from Prunus mira promoted hair growth in mice, possibly via Wnt/β-catenin signaling.
- Recurring transient lymphadenopathy after microneedling with platelet-rich plasma for androgenetic alopecia A case of recurring transient lymphadenopathy following microneedling with platelet-rich plasma for androgenetic alopecia.
- Cyclosporine With and Without Systemic Corticosteroids in Treatment of Alopecia Areata: A Systematic Review A systematic review of 340 cases found cyclosporine plus systemic corticosteroids outperformed cyclosporine alone for alopecia areata.
- Dexpanthenol may be a novel treatment for male androgenetic alopecia: Analysis of nine cases A nine-case series reported marked improvement in male androgenetic alopecia after systemic dexpanthenol treatment.
- Spironolactone for treatment of female pattern hair loss Spironolactone for the treatment of female pattern hair loss.
- PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration In cell cultures and mice, PI3K/Akt signaling was essential for de novo hair follicle regeneration from epidermal stem cells and skin precursors.
- Oral isotretinoin combined with topical clobetasol 0.05% and tacrolimus 0.1% for the treatment of frontal fibrosing alopecia: a randomized controlled trial In a small randomized trial, adding oral isotretinoin to topical clobetasol and tacrolimus improved frontal fibrosing alopecia severity more than topicals alone.
- Apremilast for extensive and treatment-resistant alopecia areata: a retrospective analysis of five patients Apremilast helped only one of five patients with extensive treatment-resistant alopecia areata.