September 202035
Oral minoxidil 5 mg in men improved hair growth but caused frequent hypertrichosis and edema, and the authors urge caution with hypertension or cardiovascular risk. 0.6 mm microneedling with minoxidil was found to improve count and thickness over 1.2 mm, while a microneedling review found density benefit but no standardized protocol. PRP combined with minoxidil was reported to increase follicle cell proliferation and improve hair morphology, and double-spin PRP in women gave higher terminal density than single-spin. Low-dose oral minoxidil in women was reported to improve frontal and vertex density with acceptable safety, though the series covered only twelve women. Sodium valproate nanovesicle gel performed comparably to minoxidil lotion with fewer adverse effects.
- Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment Oral minoxidil 5 mg daily improved hair in 30 men over 24 weeks; hypertrichosis (93%) and pedal edema (10%) were common, and the authors urge caution in men with hypertension or cardiovascular risk.
- Microneedling in androgenetic alopecia; comparing two different depths of microneedles In 60 AGA patients, adding biweekly 0.6 mm microneedling to minoxidil 5% improved hair count and thickness more than minoxidil alone, beating the 1.2 mm depth.
- Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia In 69 men with AGA, combining PRP with minoxidil looked promising, and PRP increased follicle cell proliferation and improved hair morphology.
- Comparison between single- versus double-spin prepared platelet-rich plasma injection in treatment of female pattern hair loss: clinical effect and relation to vascular endothelial growth factor In 15 women with FPHL, double-spin PRP gave higher terminal hair density than single-spin, and pre-activation with calcium gluconate added no value.
- Micro needling: A novel therapeutic approach for androgenetic alopecia, A Review of Literature A review finds microneedling shows promise for increasing hair density and thickness in AGA, especially combined with other treatments, but no standardized protocol exists.
- Efficacy and safety of oral minoxidil in female androgenetic alopecia In 12 women with AGA, low-dose oral minoxidil (0.5–2 mg) over 24 weeks improved hair density about 38% frontally and 23% at the vertex with acceptable safety.
- Systemic dexpanthenol as a novel treatment for female pattern hair loss Weekly intramuscular dexpanthenol 500 mg improved quality-of-life scores and hair satisfaction in women with FPHL, with no side effects reported.
- Altered FGF expression profile in human scalp-derived fibroblasts upon WNT activation: implication of their role to provide folliculogenetic microenvironment Lab and mouse-chamber experiments show WNT-activated scalp fibroblasts shift FGF7/FGF9 expression, and FGF9 increased the number and diameter of newly formed hair follicles.
- Characterization and management of hypertrichosis induced by low-dose oral minoxidil in the treatment of hair loss Characterization and management of hypertrichosis induced by low-dose oral minoxidil used for hair loss.
- Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia A sodium valproate nanovesicle gel performed comparably to marketed minoxidil lotion with fewer adverse effects in a small clinical study.
- Autologous activated platelet‐rich plasma in hair growth: A pilot study in male androgenetic alopecia with in vitro bioactivity investigation In 10 men, half-head PRP injections increased hair diameter and density peaking at 6 months, and PRP promoted papilla cell proliferation in vitro.
- Trichoscopy as an evaluation method for alopecia areata treatment: A comparative study In 31 patchy alopecia areata patients, both steroid injections and PRP improved trichoscopic findings and SALT scores over three months.
- Amelioration of Androgenetic Alopecia by Algal Oligosaccharides Prepared by Deep-Sea Bacterium Biodegradation Algal oligosaccharides from deep-sea bacterial degradation countered DHT signaling in human papilla cells and stimulated hair growth in mice.
- The Hair Follicle as an Interdisciplinary Model for Biomedical Research: An Eclectic Literature Synthesis A review surveying how hair follicle biology serves as a model across biomedical research fields.
- In vivo and in vitro hair growth‐promoting effect of silver and iron nanoparticles synthesized via <i>Blumea eriantha</i> DC plant extract In mice, silver nanoparticles made from Blumea eriantha extract promoted anagen hair growth, approaching minoxidil's effect at higher dose.
- Examination of androgenetic alopecia with serum biomarkers Men with AGA had higher serum inflammatory and oxidative stress markers and lower antioxidants than controls, implicating microinflammation and fibrosis.
- The biology of human hair greying A review concluding hair greying begins with declining melanogenesis in the hair bulb, driven largely by oxidative damage, and becomes irreversible once bulge melanocyte stem cells are depleted.
- Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells Extracts of three Polynesian plants increased dermal papilla cell proliferation and shifted hair-cycle gene expression toward growth in vitro.
- Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis A citrate-based antibacterial dressing accelerated wound healing and promoted hair follicle neogenesis in preclinical wound models.
- <i>‘Omics’</i> Approaches for Studying the Microbiome in Alopecia Areata A review describes how 'omics' technologies could be used to study the scalp microbiome's role in alopecia areata and other alopecias.
- Selective Elimination of NG2-Expressing Hair Follicle Stem Cells Exacerbates the Sensitization Phase of Contact Dermatitis in a Transgenic Rat Model In rats, removing NG2+ hair follicle stem cells during anagen worsened allergic contact dermatitis sensitization, suggesting these stem cells suppress skin immunity.
- [Design and clinical application of specialized protective cap for patients with alopecia after autologous hair transplantation]. A specialized protective cap after hair transplant reportedly reduced bleeding and swelling and improved graft survival and patient satisfaction.
- Spironolactone in Dermatology: Uses in Acne, Hidradenitis Suppurativa, Female Pattern Hair Loss, and Hirsutism A Spanish-language review covers spironolactone's uses, dosing, and safety in acne, hidradenitis, female pattern hair loss, and hirsutism.
- Implications of cigarette smoking on early‐onset androgenetic alopecia: A cross‐sectional Study In 1000 young men, AGA was far more prevalent among smokers than nonsmokers, though severity was not tied to smoking intensity.
- Female pattern hair loss in men: A distinct clinical variant of androgenetic alopecia Female pattern hair loss can occur in men as a distinct clinical variant of androgenetic alopecia.
- Pro-inflammatory Vδ1+T-cells infiltrates are present in and around the hair bulbs of non-lesional and lesional alopecia areata hair follicles Scalp biopsy analysis finds pro-inflammatory Vδ1+ T cells infiltrating alopecia areata follicles, suggesting a possible new treatment target.
- Low-Dose IL-2 for Treating Moderate to Severe Alopecia Areata: A 52-Week Multicenter Prospective Placebo-Controlled Study Assessing its Impact on T Regulatory Cell and NK Cell Populations A 52-week placebo-controlled study tested low-dose IL-2 for moderate-to-severe alopecia areata and its effects on immune cell populations.
- “‘You lose your hair, what’s the big deal?’ I was so embarrassed, I was so self-conscious, I was so depressed:” a qualitative interview study to understand the psychosocial burden of alopecia areata Interviews with 45 alopecia areata patients describe depression, embarrassment, social avoidance, and reliance on concealment, underscoring the condition's psychosocial burden.
- Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Lab work shows glutamine metabolism and mTORC2 signaling control whether hair follicle stem-cell progeny can return to a stem-cell state.
- Platelet factor 4 inhibits human hair follicle growth and promotes androgen receptor expression in human dermal papilla cells In cultured human follicles, platelet factor 4, a PRP component, suppressed hair growth and raised androgen receptor expression in dermal papilla cells.
- Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway In cultured human dermal papilla cells and follicles, quercitrin boosted growth factors and hair shaft growth via MAPK/CREB signaling.
- IL-36α Promoted Wound Induced Hair Follicle Neogenesis via Hair Follicle Stem/Progenitor Cell Proliferation In mice, IL-36α added to skin wounds increased regenerated hair follicles and accelerated healing via stem/progenitor cell proliferation.
- Clinical Study to Evaluate the Efficacy and Safety of a Hair Serum Product in Healthy Adult Male and Female Volunteers with Hair Fall In 42 volunteers using an amla-based hair serum for 90 days, hair density and growth rate improved and hair fall decreased, with no control group.
- Concentrated nanofat: a modified fat extraction promotes hair growth in mice via the stem cells and extracellular matrix components interaction In mice, concentrated nanofat injections promoted hair growth better than isolated fat stem cells, via Wnt/β-catenin activation in dermal papilla cells.
- Azelaic acid stimulates catalase activation and promotes hair growth through upregulation of Gli1 and Gli2 mRNA and Shh protein.