June 202036
Low-dose oral minoxidil was reported effective across non-scarring alopecias, with hypertrichosis and postural hypotension the commonest adverse effects. Adding finasteride, laser, or microneedling to minoxidil was found to beat minoxidil alone. Topical finasteride was concluded effective with a favorable safety profile. A beveled FUE punch directs grafts centrally and reduces follicle transection during harvesting. PRP graft preservation increased density versus saline. PRP for androgenetic alopecia was found to raise density, though evidence remains qualitative. Home-use microneedling with minoxidil showed the best, nonsignificant hair-count gains. SULT1A1 variants reportedly predict oral minoxidil response. Persistent post-finasteride symptoms were linked to penile vascular abnormalities; two subjects died by suicide.
- Minoxidil Sulfotransferase Enzyme (SULT1A1) genetic variants predicts response to oral minoxidil treatment for female pattern hair loss SULT1A1 enzyme genetic variants predict response to oral minoxidil treatment for female pattern hair loss.
- The edge out punch: An advancement that reduces transections in follicular unit excision hair transplantation A review describes a thicker-walled, internally beveled FUE punch that directs grafts centrally and reduces follicle transection during harvesting.
- Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature A review of 33 articles finds topical finasteride effective for male and female pattern hair loss with a favorable safety profile, though more research is needed.
- Low‐dose oral minoxidil as treatment for non‐scarring alopecia: a systematic review A systematic review of 19,218 patients finds low-dose oral minoxidil effective for androgenetic alopecia (61-100% improved), with hypertrichosis and postural hypotension the commonest adverse effects.
- Usefulness of home‐use microneedle devices in the treatment of pattern hair loss In 29 pattern hair loss patients, a home-use microneedle device combined with 5% minoxidil showed the best hair count improvements, though not statistically significant.
- The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta‐analysis Meta-analysis of 15 RCTs shows adding finasteride, laser therapy, or microneedling to minoxidil beats minoxidil alone for androgenetic alopecia.
- Penile vascular abnormalities in young men with persistent side effects after finasteride use for the treatment of androgenic alopecia Men with persistent symptoms after stopping finasteride for hair loss showed penile vascular abnormalities, depression scores, and urinary symptoms versus controls; two subjects died by suicide, in a small case-control study.
- The Utility of Platelet-Rich Plasma for the Treatment of Alopecia A systematic review finds PRP increases hair density and shaft width in androgenetic alopecia with minimal adverse events, but notes evidence is largely qualitative.
- Effect of Platelet Rich Plasma versus Saline Solution as a Preservation Solution for Hair Transplantation In a 30-patient randomized trial, preserving hair grafts in PRP rather than saline increased hair density, graft uptake, and thickness, with all PRP patients exceeding 75% regrowth.
- Prevention and Treatment of Chemotherapy-Induced Alopecia A review finds scalp cooling is the only FDA-approved prevention for chemotherapy-induced alopecia; minoxidil and bimatoprost may aid regrowth after treatment ends.
- A systematic review of the effect of platelet‐rich plasma on androgenetic alopecia of women A systematic review of six small trials (92 women) finds PRP improved hair density and diameter in female pattern hair loss.
- Intralesional betamethasone <i>versus</i> triamcinolone acetonide in the treatment of localized alopecia areata: a within-patient randomized controlled trial In a within-patient trial, triamcinolone worked earlier but betamethasone 1.75 mg/ml achieved similar regrowth by 12 weeks for alopecia areata.
- HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition In mice, the humanin analogue HNG prolonged anagen and promoted hair growth by activating Erk1/2, Akt, and Stat3 and upregulating VEGF.
- Extensive Scarring Alopecia Treated Through a Single Dense-Packing Follicular Unit Extraction Megasession In 52 patients with extensive scarring alopecia, dense-packing FUE megasessions achieved 85% graft survival and high satisfaction at 12 months.
- Transdermal Composite Microneedle Composed of Mesoporous Iron Oxide Nanoraspberry and PVA for Androgenetic Alopecia Treatment A magneto-responsive microneedle patch delivering minoxidil with mild heating produced 800% greater hair density than no treatment in mice.
- Transient stimulation of TRPV4‐expressing keratinocytes promotes hair follicle regeneration in mice A single injection of a TRPV4 activator triggered hair follicle regeneration in mice via ERK signalling, suggesting a possible new treatment strategy.
- Scalp cooling to prevent chemotherapy-induced alopecia A review concludes scalp cooling is an effective and safe strategy to prevent chemotherapy-induced alopecia.
- Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing Frontal fibrosing alopecia biopsies show Th1/JAK3 skewing and bulge immune attack, suggesting JAK-targeting treatment could prevent permanent follicle destruction.
- Study of serum vitamin D levels in men with premature androgenetic alopecia In a 50-patient case-control study, men with premature androgenetic alopecia had significantly lower vitamin D levels than controls, correlating with severity.
- Does Estradiol Level in Platelet-Rich Plasma Improve Efficacy of Androgenic Alopecia Treatment? In 30 men, homologous PRP with high estrogen levels increased hair density more and earlier than autologous PRP.
- Hair-bearing human skin generated entirely from pluripotent stem cells In the lab, human pluripotent stem cells self-assembled into skin organoids with hair follicles that formed hair-bearing skin when grafted onto mice.
- Comparative study between fractional carbon dioxide laser vs intralesional steroid injection in treatment of alopecia areata In 20 alopecia areata patients, fractional CO2 laser gave significantly better improvement, satisfaction, and hair density than intralesional steroids, without serious side effects.
- Quantitative analysis of the anatomical changes in the scalp and hair follicles in androgenetic alopecia using magnetic resonance imaging MRI showed thinner scalps and shallower hair follicles in men with androgenetic alopecia versus controls, a potential objective measurement tool.
- miR‐203a‐3p promotes loureirin A‐induced hair follicle stem cells differentiation by targeting Smad1 In rat hair follicle stem cells, miR-203a-3p promotes loureirin A-induced differentiation by targeting Smad1.
- Hair Transplantation in Endocrine Therapy–Induced Alopecia Hair transplantation is examined in patients with endocrine therapy–induced alopecia.
- Hormonal regulation in male androgenetic alopecia—Sex hormones and beyond: Evidence from recent genetic studies A review discusses genome-wide findings on hormonal signalling pathways in male androgenetic alopecia genetics.
- A new self‐reported measure of disease severity of scalp hair loss in alopecia areata A new self-reported measure of scalp hair loss severity in alopecia areata is presented.
- Exploration of potential lipid biomarkers for premature canities by UPLC‐QTOF‐MS analyses of hair follicle roots Hair follicle lipid profiling found vitamin D3 progressively decreased from pigmented to white hair in premature greying.
- Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice Conditioned medium from adipose ECM/SVF gel stimulated more hair growth than stem-cell medium in mice via dermal papilla proliferation and anagen induction.
- GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells GDNF promotes hair formation and wound healing by targeting bulge stem cells.
- Cross sectional quality of life assessment in patients with androgenetic alopecia In 400 patients, androgenetic alopecia lowered quality of life across all domains versus controls, especially younger patients and severe cases.
- Erosive pustular dermatosis of the scalp: causes and treatments A review of erosive pustular dermatosis of the scalp lists causes and finds topical tacrolimus and photodynamic therapy effective alongside steroids.
- Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cell In cell culture, exosomes from hair outer root sheath cells and platelet lysate boosted hair-inductivity markers in human dermal papilla cells.
- The first comprehensive classification of hair transection: A step forward Authors propose the first comprehensive classification of hair transection during follicular unit extraction.
- Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature Mice overexpressing kallikrein 14 show hair shaft defects from desmoglein degradation, implicating it in Netherton syndrome.
- RF-Mesotherapy With Dutasteride: A Future Alternative Treatment for Androgenetic Alopecia Spanish-language commentary proposing radiofrequency-assisted mesotherapy with dutasteride as a future option for androgenetic alopecia.