March 202027
Finasteride plus topical minoxidil outperformed either drug alone with similar safety. FUE hair transplantation improved density with high satisfaction. Autologous dermal sheath cup cells increased density and diameter in a randomized trial. FUE and FUT methods proved equally effective but differ in scarring. PRP studies mostly showed positive outcomes though long-term data are lacking. Finasteride and dutasteride in women may help where minoxidil fails though teratogenicity limits use. Urinary metabolomics after finasteride found altered steroid levels linked to post-finasteride syndrome. In mice, epidermal and dermal papilla cells induced new follicles.
- Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients after Finasteride Treatment for a Year Urinary metabolomics of MPB patients on finasteride for a year found altered androgen and estrogen levels, suggesting links to post-finasteride syndrome.
- Safety of oral bicalutamide in female pattern hair loss: A retrospective review of 316 patients A retrospective review of 316 patients examines the safety of oral bicalutamide for female pattern hair loss.
- The Efficacy and Safety of Finasteride Combined with Topical Minoxidil for Androgenetic Alopecia: A Systematic Review and Meta-analysis A meta-analysis of five RCTs found finasteride plus topical minoxidil works better than either drug alone for AGA, with similar safety.
- Hair transplantation by follicular unit extraction for male androgenetic alopecia: A retrospective observational study from two centers A two-center retrospective study found FUE hair transplantation significantly improved hair density in male AGA, with high satisfaction reported.
- Autologous cell–based therapy for male and female pattern hair loss using dermal sheath cup cells: A randomized placebo-controlled double-blinded dose-finding clinical study A randomized trial found injections of autologous dermal sheath cup cells significantly increased hair density and diameter at 6–9 months in men and women, with no serious adverse events.
- Old Friend or New Ally: A Comparison of Follicular Unit Transplantation and Follicular Unit Excision Methods in Hair Transplantation A review concludes FUE and FUT methods are equally effective for hair transplantation grafts but differ in donor-region scarring patterns.
- Platelet-Rich Plasma for Hair Restoration A review reports most PRP studies show positive hair restoration outcomes in androgenetic alopecia, but notes long-term data and standardized procedures are lacking.
- Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date A review finds oral finasteride, topical finasteride, and dutasteride may help female pattern hair loss where minoxidil fails, though use is limited by teratogenicity.
- Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration A review categorizes hair follicle stem cell niche cells into signaling, sensing, and relay modules, and links niche dysfunction to androgenetic alopecia and alopecia areata.
- Effective combination therapy with high concentration of Minoxidil and Carboxygas in resistant Androgenetic alopecia: Report of nine cases A report of nine cases found high-concentration minoxidil 20% combined with microneedling and carboxytherapy increased hair growth in resistant AGA.
- Low-level laser therapy and narrative review of other treatment modalities in androgenetic alopecia A review describes low-level laser therapy and other treatment options for androgenetic alopecia, noting that choices depend on patient needs and compliance.
- Preliminary studies of hair follicle regeneration by injections of epidermal stem cells and dermal papilla cells into nude mice Injections of epidermal stem cells mixed with dermal papilla cells induced new hair follicle structures in nude mice.
- Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement In mice, dual-frequency ultrasound with microbubble cavitation enhanced transdermal minoxidil delivery and hair growth more than single-frequency ultrasound.
- Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti‐inflammatory and antioxidant agents to treat hair loss An open-label study of 45 people found a daily anti-inflammatory and antioxidant shampoo plus lotion regimen increased anagen hairs and reduced shedding over 90 days, with no adverse events.
- Colored Polymeric Nanofiber Loaded with Minoxidil Sulphate as Beauty Coverage and Restoring Hair Loss A lab study created colored nanofibers loaded with minoxidil sulfate that show stable 6-month storage and controlled drug release.
- Extract of <i>Plumbago zeylanica</i> enhances the growth of hair follicle dermal papilla cells with down‐regulation of 5α‐reductase type II A lab study found Plumbago zeylanica extract enhances dermal papilla cell growth and downregulates SRD5A2, the gene encoding 5α-reductase type II.
- Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin A novel fibrous membrane inspired by ancient Chinese medicine, containing quercetin-copper chelates, promoted hair follicle regeneration and wound healing in burned skin.
- Early-onset androgenetic alopecia in China: a descriptive study of a large outpatient cohort A Chinese outpatient study of nearly 3,900 patients found early-onset AGA mostly affects men aged 21–30 and is often paternally inherited.
- LncRNA-XIST promotes dermal papilla induced hair follicle regeneration by targeting miR-424 to activate hedgehog signaling A lab study found lncRNA XIST promotes hair follicle regeneration by sponging miR-424 to activate hedgehog signaling in dermal papilla cells.
- 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes In mice and cultured pigment cells, 3,4,5-tri-O-caffeoylquinic acid enhanced hair pigmentation via beta-catenin activation.
- Glucose metabolism regulates expression of hair-inductive genes of dermal papilla spheres via histone acetylation In cultured dermal papilla cells, glucose-driven glycolysis maintained hair-inductive gene expression via histone acetylation.
- Androgenetic alopecia—Perspective from patients in a Singaporean tertiary Dermatology center A study describes the perspectives of patients with androgenetic alopecia at a Singapore dermatology center.
- [Wound-induced hair follicle neogenesis: a new perspective on hair follicles regeneration in adult mammals]. A Chinese review summarizes research on cell sources and signaling pathways behind wound-induced hair follicle neogenesis.
- Therapeutic options for erosive pustular dermatosis of the scalp: a systematic review* A systematic review of 168 erosive pustular dermatosis patients found low-quality evidence supporting topical corticosteroids plus calcineurin inhibitor maintenance.
- CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen Rabbits with CRISPR/Cas9-disrupted FGF5 developed systemic long hair due to prolonged anagen phase, confirming FGF5 as a negative hair growth regulator.
- Treatment of chronic alopecia areata with tildrakizumab: an open‐label pilot study An open-label pilot study tests the IL-23 inhibitor tildrakizumab for chronic alopecia areata.
- Tolerability of hair cleansing conditioners: a double-blind randomized, controlled trial designed to evaluate consumer complaints to the U.S. Food and Drug Administration A 200-person double-blind RCT found Wen cleansing conditioner as well tolerated as similar products and better tolerated than salicylic acid and baby shampoos.