November 202045
Platelet-rich plasma for androgenetic alopecia had a place in treatment, one commentary argued; a second commentary on platelet-rich plasma found clinically significant improvement lacked evidence. SULT1A1 activity in hair follicles could predict minoxidil response, a review concluded. Combination minoxidil with microneedle-delivered fibroblast growth factor was tested against either agent alone in a randomized trial. Dutasteride users with pattern hair loss reported fewer COVID-19 symptoms than non-users. Biochemical hyperandrogenism in women showed no association with hair-loss severity. Vertical scalp mobility measurement was found to yield more hairs from donor strips than horizontal. Videodermoscopy in female pattern hair loss matched scalp biopsy for specificity. Scalp micropigmentation showed minimal fading and high satisfaction. Cold plasma scalp treatment was reported well tolerated, though efficacy was not formally tested. A mutant FGF5s protein was found to increase total hair count.
- Platelet-rich plasma has a place in the treatment of androgenetic alopecia a commentary arguing platelet-rich plasma has a place in treating androgenetic alopecia.
- Adverse effects of low-dose oral minoxidil for androgenetic alopecia in 435 patients a report on adverse effects of low-dose oral minoxidil for androgenetic alopecia in 435 patients.
- Platelet-rich plasma lacks evidence of clinically significant improvement in androgenetic alopecia a commentary arguing platelet-rich plasma lacks evidence of clinically significant improvement in androgenetic alopecia.
- Ongoing Concerns Regarding Finasteride for the Treatment of Male-Pattern Androgenetic Alopecia a JAMA Dermatology piece raising ongoing concerns about finasteride for male-pattern hair loss.
- Combination therapy with topical minoxidil and nano-microneedle-assisted fibroblast growth factor for male androgenetic alopecia: a randomized controlled trial in Chinese patients A randomized trial in 40 Chinese men compared minoxidil, microneedle-delivered fibroblast growth factor, and the combination for androgenetic alopecia over 16 weeks.
- Sulfotransferase SULT1A1 activity in hair follicle, a prognostic marker of response to the minoxidil treatment in patients with androgenetic alopecia: a review A review: measuring SULT1A1 enzyme activity in hair follicles could predict which androgenetic alopecia patients will respond to topical minoxidil.
- 5‐alpha‐reductase inhibitors are associated with reduced frequency of COVID‐19 symptoms in males with androgenetic alopecia In a matched cohort of Brazilian men with androgenetic alopecia, dutasteride users had significantly fewer COVID-19 symptoms than non-users.
- Is There Any Association Between Clinical and Biochemical Hyperandrogenism in Women With Female Pattern Hair Loss? In 362 women with female pattern hair loss, biochemical hyperandrogenism showed no association with hair loss severity, unlike hirsutism and acne.
- Vertical or horizontal scalp mobility: What to assess In 15 hair transplant patients, measuring scalp mobility vertically rather than horizontally yielded about 970 more hairs from the same donor strip.
- Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells Lab study: the Wnt agonist R-spondin-1 restored hair follicle neogenesis from adult mouse cells in skin reconstitution assays.
- Targeting of the Pilosebaceous Follicle by Liquid Crystal Nanocarriers: In Vitro and In Vivo Effects of the Entrapped Minoxidil Minoxidil in liquid-crystal nanocarriers selectively reached pilosebaceous follicles, improving effectiveness and duration while reducing side effects versus conventional formulation.
- Identification of novel step‐up regimen of intralesional triamcinolone acetonide in scalp alopecia areata based on a double‐blind randomized controlled trial A 105-patient randomized trial found all triamcinolone concentrations beat saline for scalp alopecia areata, but 10 mg/mL caused the most atrophy; starting at 2.5 mg/mL and stepping up is proposed.
- The Potential Role of Nutraceuticals as an Adjuvant in Breast Cancer Patients to Prevent Hair Loss Induced by Endocrine Therapy A review weighs nutraceuticals to prevent endocrine-therapy hair loss in breast cancer patients, stressing unclarified interactions with therapy.
- Scalp Micropigmentation Procedure: A Useful Procedure for Hair Restoration In 22 patients, scalp micropigmentation gave minimal fading over 20 months, one allergic reaction, and 80% satisfaction.
- Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia A review of gene, cell and tissue-engineering therapies being studied for alopecia areata and androgenetic alopecia.
- Defining microRNA signatures of hair follicular stem and progenitor cells in healthy and androgenic alopecia patients Lab study: miR-324-3p is dysregulated in balding follicle stem cells, and blocking TGF-β signalling promoted hair shaft elongation in organ culture.
- Accuracy of clinical diagnosis and videodermoscopy in female pattern hair loss Videodermoscopy diagnosed female pattern hair loss with 88.9% sensitivity and 100% specificity against scalp biopsy, suggesting it may replace biopsy.
- Comparative Graft Survival Study of Follicular Unit Excision Grafts With or Without Minor Injury In mice, injured FUE grafts survived worse than intact ones: 71% intact, 51% pared, 44% bulb-injured, 13% fractured.
- A Retrospective Comparative Study of Two Concentrations of Intralesional Triamcinolone Acetonide in the Treatment of Patchy Alopecia Areata on the Scalp In 85 patients with patchy scalp alopecia areata, intralesional triamcinolone 5 mg/mL worked as well as 10 mg/mL, with similar minor side effects and about 45% recurrence.
- Effect of cysteine‐free human fibroblast growth factor‐5s mutant ( FGF5sC93S ) on hair growth A mutant FGF5s protein applied to scalps increased total hair count at 24 weeks in human subjects, blocking FGF5-driven catagen.
- The Inflammatory Aspect of Male and Female Pattern Hair Loss A review highlights perifollicular inflammation and inflammatory genes as features of male and female pattern hair loss, suggesting future treatment targets.
- Tolerability of Six Months Indirect Cold (Physical) Plasma Treatment of the Scalp for Hair Loss In a 14-patient pilot study, indirect cold plasma scalp treatment for pattern hair loss was well tolerated over up to six months, with most patients reporting improvement, though efficacy was not formally tested.
- Optimal Management of Frontal Fibrosing Alopecia: A Practical Guide A review offers clinicians a practical, evidence-based guide to managing frontal fibrosing alopecia, which has no standard treatment.
- Thiolated and PEGylated silica nanoparticle delivery to hair follicles In pig skin, PEG-coated silica nanoparticles penetrated hair follicles, with 5000-Da PEG reaching deeper than 750-Da PEG, while uncoated particles stayed on the surface.
- Androgens downregulate BMP2 impairing the inductive role of dermal papilla cells on hair follicle stem cells differentiation In cultured cells, androgens downregulated BMP2 in dermal papilla cells, impairing hair follicle stem cell differentiation; adding BMP2 restored it.
- Androgenetic alopecia may be associated with weaker COVID-19 T-cell immune response: An insight into a potential COVID-19 vaccine booster a hypothesis that androgenetic alopecia may signal weaker T-cell response to COVID-19, with vaccine booster implications.
- Green fabrication of seedbed-like Flammulina velutipes polysaccharides–derived scaffolds accelerating full-thickness skin wound healing accompanied by hair follicle regeneration In a rat wound model, mushroom-derived polysaccharide scaffolds accelerated skin healing and induced hair follicle regeneration.
- Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases In pig skin and mice, tofacitinib-loaded squalenyl nanoparticles improved follicular delivery and reduced inflammation, supporting development of topical therapy for alopecia areata.
- “Two-Cell Assemblage” Assay: A Simple in vitro Method for Screening Hair Growth-Promoting Compounds Researchers developed a 3D two-cell co-culture assay that screens many candidate hair-growth compounds at once by measuring structure elongation.
- Hair Follicle Targeting and Dermal Drug Delivery with Curcumin Drug Nanocrystals—Essential Influence of Excipients In skin models, the choice of excipient strongly affected follicle targeting of curcumin nanocrystals: ethanol enhanced follicle delivery, glycerol hindered it, propylene glycol boosted both routes.
- The antiinflammatory effects of Xuefu Zhuyu decoction on C3H/HeJ mice with alopecia areata In stressed AA mice, Xuefu Zhuyu herbal decoction regrew hair by lowering inflammatory factors IL-6, IL-1β, TNF-α and osteopontin.
- Microneedles mediated bioinspired lipid nanocarriers for targeted treatment of alopecia microneedle-mediated lipid nanocarriers for targeted alopecia treatment.
- Bidirectional association between alopecia areata and migraine: A nationwide population-based cohort study a nationwide population-based cohort study examined a bidirectional association between alopecia areata and migraine.
- Mammalian-specific ectodermal enhancers control the expression of <i>Hoxc</i> genes in developing nails and hair follicles In mice, deleting the HoxC gene cluster caused loss of nails and hair, identifying two mammal-specific enhancers controlling these genes in developing hair and nails.
- Para rubber seed oil: The safe and efficient bio‐material for hair loss treatment In cell experiments, para rubber seed oil stimulated dermal papilla cell proliferation comparably to minoxidil and weakly inhibited 5-alpha-reductase.
- Novel complex of cosmetic ingredients with promising action in preventing hair loss and follicular aging through mechanism involving enrichment of <i>WNT</i>/signaling, mitochondrial activity, and stem cells maintenance In cell and scalp cultures, a nanoencapsulated cosmetic ingredient complex boosted WNT signaling and mitochondrial activity, reduced DHT production, and limited UV-induced follicle aging markers.
- Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles Genome-wide mapping found 374 gene-regulation variants in scalp hair follicles, suggesting a new candidate gene at androgenetic alopecia loci.
- The microfollicle: a model of the human hair follicle for in vitro studies A 3D 'microfollicle' organoid model responded to minoxidil with gene-expression changes overlapping up to 75% with human clinical samples, supporting preclinical testing use.
- Epidermal Stem Cells in Hair Follicle Cycling and Skin Regeneration: A View From the Perspective of Inflammation A review links immune cells and inflammation to hair follicle stem cell activation, cycling and wound-induced follicle neogenesis.
- A Cross-sectional Study of Plasma Trace Elements and Vitamins Content in Androgenetic Alopecia in Men In 50 men with androgenetic alopecia, zinc, copper, magnesium, selenium and vitamin deficiencies were common but did not correlate with hair loss rate.
- Rescuing key native traits in cultured dermal papilla cells for human hair regeneration Keratinocyte-conditioned medium restored hair-inducing ability in cultured human dermal papilla cells, which then formed hair follicle-like structures when grafted into mice.
- Effects of Adipose-Derived Stem Cells and Platelet-Rich Plasma for Prevention of Alopecia and Other Skin Complications of Radiotherapy In mice with transplanted human follicles, adipose stem cells plus platelet-rich plasma prevented radiotherapy-induced alopecia and skin damage.
- Brigham Eyebrow Tool for Alopecia: A Reliable Assessment of Eyebrow Alopecia Areata The Brigham Eyebrow Tool for Alopecia showed high reliability (ICC ~0.9) for quantifying eyebrow loss in alopecia areata.
- Latanoprost Loaded in Polymeric Nanocapsules for Effective Topical Treatment of Alopecia In pig skin, latanoprost-loaded nanocapsules delivered 30% more drug into hair follicles than a control solution, doubled further by massage, in a stable, non-irritating formulation.
- Immunology of alopecia areata A review outlines evidence that alopecia areata is an autoimmune disease involving collapse of hair follicle immune privilege, though no specific target autoantigen has been identified.