October 202032
A herbal solution with 5% minoxidil improved hair diameter and density more than minoxidil alone. A botanical combination versus 3% minoxidil performed similarly to minoxidil. Low-level light therapy with minoxidil improved density and diameter more than either treatment alone in women. A phyto-caffeine shampoo reduced hairs lost on pull test versus control shampoo. Hormone testing in female pattern hair loss rarely showed abnormalities despite symptoms suggesting hormonal problems. A Brazilian survey found baldness and grey hair associated with more severe COVID-19. In children with alopecia areata, oral tofacitinib gave a median 67.7% SALT improvement.
- Efficacy and safety of a novel herbal solution for the treatment of androgenetic alopecia and comparison with 5% minoxidil: A double‐blind, randomized controlled trial study In a 24-man randomized trial, adding a topical herbal solution to 5% minoxidil improved hair diameter and density more than minoxidil alone over 9 months.
- Is hormone testing worthwhile in patients with female pattern hair loss? In 106 women with pattern hair loss, hormone testing rarely showed abnormalities even when symptoms suggested hormonal problems, questioning routine testing.
- Comparison of low-level light therapy and combination therapy of 5% minoxidil in the treatment of female pattern hair loss In a 90-woman randomized trial, combining low-level light therapy with 5% minoxidil improved hair density and diameter more than either alone.
- Efficacy of a cosmetic phyto-caffeine shampoo in female androgenetic alopecia In a randomized trial of women with pattern hair loss, a phyto-caffeine shampoo reduced hairs lost on pull test more than a control shampoo over 6 months.
- An Herbal Extract Combination (Biochanin A, Acetyl tetrapeptide-3, and Ginseng Extracts) versus 3% Minoxidil Solution for the Treatment of Androgenetic Alopecia: A 24-week, Prospective, Randomized, Triple-blind, Controlled Trial In a 24-week triple-blind trial, a botanical combination of biochanin A, acetyl tetrapeptide-3 and ginseng performed similarly to 3% minoxidil for pattern hair loss.
- Proposed mechanisms of low-level light therapy in the treatment of androgenetic alopecia A review proposes that low-level light therapy regrows hair via nitric oxide and redox signaling, but optimal parameters and long-term safety remain unstudied.
- Treatment of alopecia areata in pre‐adolescent children with oral tofacitinib: A retrospective study In 14 children with alopecia areata, oral tofacitinib gave a median 67.7% SALT improvement over 9 months with mild adverse events.
- Alopecia and grey hair are associated with COVID‐19 Severity In a 43,595-person Brazilian survey, baldness and extensive grey hair were independently associated with more severe COVID-19.
- Low-dose oral minoxidil for treating alopecia: A 3-year North American retrospective case series a 3-year North American retrospective case series of low-dose oral minoxidil for treating alopecia.
- Hair growth promotion by Necrostatin-1s The RIPK1 inhibitor Necrostatin-1s promoted hair growth in human outer-root-sheath cells and mouse and pig follicle cultures by blocking necroptosis and activating Wnt/β-catenin.
- Fisetin Promotes Hair Growth by Augmenting TERT Expression In mice, fisetin and resveratrol boosted TERT, shifted follicles into growth phase and promoted hair growth.
- Metabolic syndrome in androgenetic alopecia patients; Is serum regulated on activation, normal T‐cell expressed and secreted the missing link? Metabolic syndrome was three times more common in AGA patients than controls, with higher RANTES levels, in a 160-subject study.
- Microscopy‐guided laser ablation for the creation of complex skin models with folliculoid appendages Laser-ablated collagen hydrogels guided keratinocytes to form follicle-like structures in an engineered skin model.
- Láser de baja potencia para tratar la alopecia androgénica A Spanish-language review notes that low-level laser therapy significantly increased hair density versus sham in a 2019 meta-analysis of androgenetic alopecia trials.
- Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells In cultured human dermal papilla cells, the plant scent compound nonanal boosted growth factor production via cAMP signaling.
- Risks of Skin, Hair, and Nail Supplements A review warns that unregulated beauty supplements carry documented risks including toxicity, drug interactions, and possible cancer risk, and urges physician education.
- Forging the Future: 2018 Alopecia Areata Research Summit Summary Report A 2018 alopecia areata research summit summarized progress and set future research priorities.
- Platelet-Rich Plasma in the Treatment of Alopecia Areata: A Review A review finds PRP relatively safe and potentially helpful for alopecia areata but with no standardized protocol.
- Alopecia Areata: A Complex Cytokine Driven Disease A review describes alopecia areata as driven by overlapping Th1 and Th2/IL-23 cytokine pathways, calling for targeted trials.
- A Botanical Compound for the Treatment of Alopecia Areata and Chemotherapy-Induced Alopecia A topical botanical drug in late-stage trials for alopecia areata and chemotherapy-induced alopecia shows a promising early trend, but no conclusions yet.
- The Role of Patients in Alopecia Areata Endpoint Development: Understanding Physical Signs and Symptoms Interviews with 30 alopecia areata patients found scalp hair loss their most bothersome symptom, guiding trial endpoint development.
- DNMT1-mediated methylation inhibits microRNA-214-3p and promotes hair follicle stem cell differentiate into adipogenic lineages In hair follicle stem cells, DNMT1 methylation of miR-214-3p promoted fat-cell differentiation and aided skin regeneration in mice.
- Photoacoustic Imaging as a Tool for Assessing Hair Follicular Organization Photoacoustic imaging measured hair follicle density and angles, correlating closely with photographic counts, aiding transplant planning.
- Wound Induced Hair Neogenesis – A Novel Paradigm for Studying Regeneration and Aging A review of wound-induced hair neogenesis explores follicle regeneration and how it may decline with age.
- Hair follicle bulge-derived stem cells promote tissue regeneration during skin expansion In rats, transplanted follicle bulge stem cells enhanced regeneration of expanded skin via new cell types and growth factors.
- Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes In cultured human follicle cells, FOXA2 activity maintained hair-inducing ability, which fades with longer time in culture.
- Consensus on the treatment of alopecia areata – Brazilian Society of Dermatology A Brazilian consensus recommends intralesional corticosteroids first for localized alopecia areata, systemic steroids for extensive active disease.
- Preparing the hair follicle canal for hair shaft emergence In mouse skin, K79-positive cells die back to open the follicle canal so the hair shaft can emerge.
- A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review A review surveys marketed topical products, natural products and supplements for pattern hair loss.
- Association of Baldness with Coronary Artery Disease and Its Severity In 105 Iranian men undergoing angiography, baldness tripled the likelihood of coronary artery disease though not its severity.
- Hair follicle targeting with curcumin nanocrystals: Influence of the formulation properties on the penetration efficacy In pig ear skin, curcumin nanocrystals penetrated hair follicles well from simple gels, but humectants reduced follicle targeting.
- Hair‐pulling disorder (Trichotillomania): Etiopathogenesis, diagnosis and treatment in a nutshell