May 202027
A topical booster enhancing follicular sulfotransferase was reported in lab work to convert minoxidil non-responders into responders. Topical adipose stem cell extract increased hair count versus vehicle in a randomized trial. Microneedling combined with 5% minoxidil outperformed either treatment alone in Chinese men. A meta-analysis of PRP found increased hair density and thickness in pattern hair loss. Cow placenta extract lotion raised hair counts as much as minoxidil 2% in women with pattern hair loss. Baseline plasma zinc predicted response to topical minoxidil in men. In rats, a cyclodextrin-minoxidil gel reduced the cardiac hypertrophy and hypotension caused by high-dose minoxidil solution, though human relevance is unproven.
- Efficacy and safety of very-low-dose oral minoxidil 1.25 mg in male androgenetic alopecia A study of efficacy and safety of very-low-dose oral minoxidil 1.25 mg in male androgenetic alopecia.
- Novel topical booster enhances follicular sulfotransferase activity in patients with androgenetic alopecia: a new strategy to improve minoxidil response A topical booster enhanced follicular sulfotransferase activity and could convert minoxidil non-responders into responders, pending clinical trial confirmation.
- A randomized, double-blind, vehicle-controlled clinical study of hair regeneration using adipose-derived stem cell constituent extract in androgenetic alopecia In a 38-patient RCT, topical adipose stem cell extract increased hair count 28.1% versus 7.1% with vehicle at 16 weeks.
- Clascoterone as a novel treatment for androgenetic alopecia Clascoterone presented as a novel treatment for androgenetic alopecia.
- Platelet-rich plasma as a therapy for androgenic alopecia: a systematic review and meta-analysis A meta-analysis of 30 studies found PRP increases hair density and thickness in androgenetic alopecia without serious adverse effects.
- Randomized trial of electrodynamic microneedling combined with 5% minoxidil topical solution for treating androgenetic alopecia in Chinese males and molecular mechanistic study of the involvement of the Wnt/β-catenin signaling pathway In a Chinese RCT, microneedling combined with 5% minoxidil beat either treatment alone, with Wnt/β-catenin pathway activation.
- Treatment of male and female pattern hair loss with sublingual minoxidil: a retrospective case‐series of 64 patients A 64-patient retrospective case series treated male and female pattern hair loss with sublingual minoxidil.
- A randomized, single‐blinded, vehicle‐controlled study of a topical active blend in the treatment of androgenetic alopecia In a 44-patient RCT, a Redensyl-based topical lotion improved self-assessed growth and anagen-to-telogen ratio with no significant adverse events.
- Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth In lab work and early clinical trials, MIF-rich stem cell conditioned medium boosted hair density, thickness, and growth rate via VEGF signaling.
- Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness In 48 men on topical minoxidil, baseline plasma zinc above 10 µmol/L predicted treatment success with 72% predictive value.
- Is there a therapeutic effect of botulinum toxin on scalp alopecia? Physiopathology and reported cases: A systematic review of the literature A systematic review of 94 patients found botulinum toxin for alopecia unproven, with mixed results and only one placebo-controlled study.
- The hydroxypropyl‐β‐cyclodextrin‐minoxidil inclusion complex improves the cardiovascular and proliferative adverse effects of minoxidil in male rats: Implications in the treatment of alopecia In rats, high-dose topical minoxidil solution caused cardiac hypertrophy, hypotension and proliferative lesions, while a cyclodextrin gel formulation reduced these effects; human relevance is unproven.
- Evaluation of the efficacy and safety of cow placenta extract lotion versus minoxidil 2% in the treatment of female pattern androgenetic alopecia In 90 women with pattern hair loss, cow placenta extract lotion raised hair counts as much as minoxidil 2% over six months.
- A transcriptomic map of murine and human alopecia areata Single-cell sequencing of mouse and human alopecia areata revealed clonally expanded CD4+ and CD8+ T cells driving autoimmune attack.
- Innovations hair restoration surgeons have made to adapt to the challenges of follicular unit excision A review of FUE punches and motorized devices describes how modern tools minimize follicle transection during harvesting.
- Androgenetic alopecia present in the majority of patients hospitalized with COVID-19: The “Gabrin sign” Androgenetic alopecia was present in most patients hospitalized with COVID-19, dubbed the 'Gabrin sign'.
- Current advances in stem cell-based therapies for hair regeneration A review of stem cell-based and conditioned-medium therapies for hair regeneration, their mechanisms, merits, and limitations.
- Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development In mice, Dicer but not Tarbp2 in bulge stem cells is required for induced anagen hair follicle growth.
- FR-Mesoterapia con dutasterida, una futura alternativa para el tratamiento de la alopecia androgenética A Spanish-language article discusses intradermal dutasteride injection (mesotherapy) as a future alternative for androgenetic alopecia.
- Polygonum multiflorum extract support hair growth by elongating anagen phase and abrogating the effect of androgen in cultured human dermal papilla cells In cultured human dermal papilla cells, Polygonum multiflorum extract prolonged anagen and countered DHT effects.
- Immune modulation of hair follicle regeneration A review of how immune modulation affects hair follicle regeneration.
- Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern Hair Loss and Telogen Effluvium A review proposes follicular proteoglycan loss drives pattern hair loss and recommends Nourkrin marine proteoglycan supplements as add-on therapy.
- Getting under the skin of hair aging: the impact of the hair follicle environment A review argues age-related changes in scalp skin likely contribute to hair aging and thinning.
- Vitamin D in trichology: a comprehensive review of the role of vitamin D and its receptor in hair and scalp disorders A review finds vitamin D and its receptor matter for hair follicle integrity, but evidence for supplementing in alopecia remains contradictory.
- Immunostaining study of cytokeratins in human hair follicle development Immunostaining of fetal skin mapped cytokeratin expression patterns during human hair follicle development.
- The clinical effect of plum blossom needle acupuncture with qi-invigorating superficies-consolidating therapy on seborrheic alopecia In an 87-patient trial, plum blossom needle acupuncture plus Chinese medicine beat conventional Western treatment for seborrheic alopecia (95% vs 81% effective rate).
- Nonpharmacological treatment approach in trichotillomania (hair‐pulling disorder)