January 2000 in “Time to knit” This article describes the extraction and characterization method for wedelolactone from Eclipta alba but presents no new clinical results.
25 citations
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January 2006 in “Journal of the European Academy of Dermatology and Venereology” This study reported that a new extraction technique using cautery and forceps is a simple, effective treatment and diagnostic procedure for eruptive vellus hair cysts, with no recurrence after 4 months.
This review discusses the potential of extracellular vesicles from various sources for skin rejuvenation and cosmetic use, noting promising results, especially with mesenchymal stem cell-derived vesicles, but reports no new clinical results.
April 2023 in “Dermatology practical & conceptual” This study concluded that lenalidomide significantly induces the proliferation and migration of melanocyte stem cells, enhancing their differentiation into functional melanocytes in a mouse model.
22 citations
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April 2022 in “Stem cell research & therapy” This study found that extracellular vesicles derived from hair follicle mesenchymal stromal cells demonstrated similar potential to those from adipose tissue in promoting cell proliferation and migration, enhancing angiogenesis, and protecting cells under stress, suggesting promise for chronic wound treatment.
In this study conducted at Shafa Hospital, Kerman, Iran, 3.5% of patients using sodium valproate as an antiepileptic experienced hair loss and curling over ten years.
December 2023 in “Asian journal of beauty & cosmetology” 23 citations
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June 1993 in “PubMed” This study found that a vitamin B-group and L-cystine combination therapy improved hair quality and growth in women with diffuse effluvia, with one formulation showing greater efficacy than another and both performing better than placebo.
2 citations
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May 2018 in “Dermatologic Surgery” This overview outlines the Dermatologic Surgery journal's comprehensive focus on cosmetic and reconstructive procedures, but it does not present any new research findings.
January 2009 in “Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine” In this study, Yifa compound treatment significantly improved female pattern hair loss and reduced sera DHT and DHEA levels after six months.
This study found that platelet-derived extracellular vesicles from apheresis platelets may effectively activate dermal papilla cells and promote hair follicle growth in a mouse model of hair regeneration.
2 citations
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April 2022 in “PLoS ONE” This study reports that short exposure to vibration causes epithelial cells to retract filopodia, concentrate actin at their edges, and increase expression of the protease calpain, suggesting a mechanism for vibration-induced pain relief.
1 citations
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September 2025 in “International Journal of Drug Delivery Technology” This randomized controlled study reported that combining Ecklonia cava with Diane-35 significantly improved weight, waist circumference, hormonal balance, and inflammation markers in women with polycystic ovary syndrome over three months compared to Diane-35 alone.
January 2021 in “Indian Journal of Paediatric Dermatology” Topical tretinoin 0.025% cream is an effective treatment for Eruptive Vellus Hair Cysts in children.
1 citations
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December 1982 in “PubMed” In this study, sodium valproate as monotherapy stopped seizures in 50% of epileptic children and was most effective in primary generalized and photosensitive epilepsies with notable side effects.
January 2025 in “International Journal of Pharmacology” This study observed significant clinical effects, such as hair loss and testicular changes, in common quail treated with the steroids IVF-C Inj and Diane-35, especially highlighting cyproterone acetate's impact on vital organs like the liver.
5 citations
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December 2014 in “Medicine and Pharmacy Reports” This study found that antiandrogenic therapy with Melleva 35 for three months was effective in reducing hair loss and improving acne in women with both Androgenetic Alopecia and Acne Vulgaris.
8 citations
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January 1977 in “Acta Haematologica” This study found that the PVP protocol, combining Peptichemio, vincristine, and 6-methylprednisolone, resulted in remission for diffuse non-Hodgkin's lymphomas with moderate side effects.
6 citations
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May 2018 in “Plant Cell, Tissue and Organ Culture (PCTOC)” This study found that adjusting plant growth conditions, such as the use of elicitors like yeast extract and methyl jasmonate, increased wedelolactone production in Eclipta alba cell suspension culture.
1 citations
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April 2010 in “Cancer Research” In preclinical studies, a B-Raf inhibitor called WYE-130600 caused dose-related skin effects in dogs and rats, suggesting potential similar responses might occur in humans.
April 2017 in “Journal of dermatology & cosmetology” In this controlled study, a 6-month treatment with the nutraceutical product ViviScal® reduced telogen hair fibers and increased total hair fibers in 83% of participants with Telogen Effluvium, who also reported improved hair and nail growth, skin appearance, and overall quality of life.
297 citations
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January 2002 in “Development” In this study, repressing β-catenin/Lef1 signalling in mouse epidermis led to progressive hair loss, dermal cysts, and spontaneous skin tumors with sebaceous differentiation, indicating altered keratinocyte differentiation and potential tumourigenic processes.
January 2026 in “Indian Journal of Plastic Surgery” This study evaluated nonculture epidermal suspension for stable vitiligo and found it to be effective, with 68% mean repigmentation and 43.1% of patients achieving excellent results; it showed sustained benefits over long-term follow-up and was generally safe with minor adverse events in 13.7% of participants.
1 citations
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November 2024 in “Pharmaceutical Sciences” This review study found that vesicular carriers like liposomes, niosomes, invasomes, and transferosomes can enhance drug penetration through follicles, benefiting treatments for alopecia, acne, and infections, as well as potentially facilitating systemic delivery of antihypertensive drugs and insulin.
8 citations
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June 2022 in “International Journal of Molecular Sciences” This review discusses the potential of extracellular vesicles for facial aesthetic applications, including scar reduction and skin rejuvenation, but reports no new clinical results; further research into production and mechanisms is needed.
45 citations
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October 2018 in “JCI Insight” In a preclinical mouse model, this study found that early treatment with the selective SYK inhibitor entospletinib significantly improved survival rates and clinical outcomes for graft-versus-host disease after hematopoietic stem cell transplantation compared to placebo.
September 2026 in “Repository of the University of Ljubljana (University of Ljubljana)” This study analyzed hair styling mousses on the Slovenian market, finding that their formulations primarily rely on polymers, with no banned ingredients according to European cosmetics regulations.
January 2021 in “Indonesian Journal on Medical Science” This study concluded that a hair tonic combining aloe vera and celery extracts can be formulated, with formula 1 meeting the stability requirements best over a month.
4 citations
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February 2019 in “Revista da Associação Médica Brasileira” This study found that FOLFOX6 chemotherapy significantly decreased serum VEGF and CRP levels in advanced colorectal cancer patients, improved their quality of life as measured by KPS scores, and demonstrated a high overall therapeutic efficacy of 82.72% with manageable side effects.
October 1997 in “Dermatologic Surgery” The Epilight Hair Removal System is effective for temporary hair removal with few side effects, but more research is needed to confirm its safety and long-term results.