SYK Inhibitor Entospletinib Prevents Ocular and Skin GVHD in Mice

    October 2018 in “ JCI Insight ”
    Jonathan C. Poe, Wei Jia, Julie A. Di Paolo … Stefanie Sarantopoulos
    Studysummary In a preclinical mouse model, this study found that early treatment with the selective SYK inhibitor entospletinib significantly improved survival rates and clinical outcomes for graft-versus-host disease after hematopoietic stem cell transplantation compared to placebo.
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