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research Rapid full engraftment and successful immune reconstitution after allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning in Omenn syndrome

8 citations , August 2009 in “Pediatric transplantation”

This report presents a case where a patient with Omenn syndrome, complicated by cytomegalovirus infection, was successfully treated using reduced intensity conditioning allogeneic HSCT from a sibling donor.

research T-Cell Reconstitution after Thymus Xenotransplantation Induces Hair Depigmentation and Loss

7 citations , January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that thymus transplantation in athymic mice resulted in T-cell-driven hair follicle depigmentation and loss, without multiorgan autoimmune disease, highlighting mechanisms of tissue-specific tolerance.

research SYK inhibitor entospletinib prevents ocular and skin GVHD in mice

45 citations , October 2018 in “JCI Insight”

In a preclinical mouse model, this study found that early treatment with the selective SYK inhibitor entospletinib significantly improved survival rates and clinical outcomes for graft-versus-host disease after hematopoietic stem cell transplantation compared to placebo.

research Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

418 citations , January 2018 in “Journal of Investigative Dermatology”

This study identified at least four distinct fibroblast populations in adult human skin, each with unique functional properties, suggesting potential therapeutic applications for wound healing and fibrosis-related diseases.

research Strategies to utilize iPS cells for hair follicle regeneration and the treatment of hair loss disorders

January 2021 in “Elsevier eBooks”

This review discusses the potential of human induced pluripotent stem cells for regenerating hair follicles and developing cell-based therapies for hair loss, but it reports no new clinical results.

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community Any interesting future treatments around the corner

7 upvotes 6 years ago

Potential future hair loss treatments include stem cell therapy, Clascosterone (Breezula), Amplifica's signaling molecules, Botox, and dutasteride mesotherapy. Some treatments are promising but expensive, like Tsuji's technique, while others, like Botox, show unexpected results.

community A Study I came along by mistake researching (Dutasteride +Pumpkin seed oil ) for every other day use.

16 upvotes 3 months ago

Alternating Dutasteride with pumpkin seed oil may protect the spleen from damage caused by Dutasteride. Pumpkin seed oil's antioxidants help counteract oxidative stress and immune suppression.

community If we can clone a sheep why we can't cure baldness till now

in Research/Science 181 upvotes 1 year ago

Hair loss treatments like Minoxidil, finasteride, and stem cell therapies exist, but a complete cure is hindered by genetic complexity and market dynamics. Cloning hair follicles is considered a potential solution, but it's currently not feasible.

community The new growth in hair loss research: With increasing evidence of its impact on mental health, scientists are pushing forward with breakthroughs on balding. Later this year, scientists will launch one of the first ever clinical trials with hair follicles grown entirely from stem cells.

324 upvotes 7 years ago

Hair loss impacts mental health, with treatments like Minoxidil, finasteride, and stem cell transplants discussed. There is hope for future breakthroughs, but current treatments are limited, and awareness is lacking.

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learn Rapamycin

Immune-suppressing drug, also called sirolimus

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