66 citations
,
July 2003 in “International Journal of Dermatology” This study found that betamethasone valerate foam was more effective and well-tolerated than betamethasone dipropionate lotion in treating mild-to-moderate alopecia areata, with higher hair regrowth rates observed.
9 citations
,
April 1987 in “International Journal of Dermatology” This article reviews rosacea and rosacea-like demodicidosis, discussing historical findings, but provides no new clinical results; the authors highlight the role of Demodex in related skin conditions.
7 citations
,
April 1987 in “International Journal of Dermatology” This article reports no new clinical findings and provides no abstract, focusing on imipramine-induced lesions resembling alopecia areata.
December 2025 in “Cosmoderma” This study reviewed evidence suggesting that systemic corticosteroids, particularly in pulse regimens like dexamethasone and betamethasone oral mini-pulse, effectively slow vitiligo progression and support repigmentation, while offering a favorable safety profile compared to continuous therapy.
5 citations
,
June 2012 in “PubMed” This article discusses leukocytoclastic vasculitis, particularly its triggers, manifestations, and treatments, and reports no new experimental results; the authors highlight valproic acid's association with this condition.
January 2024 in “Archives of dermatological research” In this clinical study, researchers reported that both sodium valproate-loaded nanospanlastics and topical corticosteroids showed comparable modest efficacy in treating patchy alopecia areata, recommending further investigation into sodium valproate's role combined with other therapies.
1 citations
,
January 1999 in “The European journal of contraception & reproductive health care” This study found that a low-dose oral contraceptive containing dienogest provides effective contraception, improves cycle stability, and may reduce excessive scalp and skin oiliness, with high user satisfaction.
59 citations
,
October 1976 in “Acta Neurologica Scandinavica” This study found that sodium valproate significantly reduced seizure frequency by over 50% in about 70% of patients with generalized seizures but was less effective for partial seizures.
2 citations
,
September 2014 in “International Journal of Dermatology” Sodium valproate can worsen psoriasis-like skin conditions.
5 citations
,
January 2017 in “Nevrologiâ, nejropsihiatriâ, psihosomatika” In this study, sustained-release sodium valproate showed high efficacy in achieving seizure remission for adults with focal and generalized epilepsy over one year, but side effects like weight gain and tremor were more frequent among heterozygous carriers of certain gene variants.
December 2011 in “InTech eBooks” This review discusses the potential role of systemic corticosteroids in the treatment of progressive vitiligo, but reports no new clinical results and suggests further research is needed.
80 citations
,
November 1975 in “Acta dermato-venereologica” This study found that while some patients with severe alopecia areata responded to high-dose prednisolone, the response was inconsistent and the therapy's risks prevent recommending it for general use.
111 citations
,
February 1991 in “Headache The Journal of Head and Face Pain” In this study, two-thirds of patients with persistent chronic daily headache significantly improved with divalproex sodium treatment, while liver functions remained unaffected.
7 citations
,
June 2000 in “Journal of the American Academy of Dermatology” This study found that betamethasone valerate in a foam vehicle has comparable total coverage to traditional topical corticosteroid vehicles, despite less coverage per unit of foam.
1 citations
,
October 2023 in “Journal of clinical psychopharmacology” In this case report, a young male developed bilateral pleural effusion and persistent fever after starting divalproex sodium for bipolar disorder, which improved upon discontinuation of the drug, suggesting a possible link between divalproex sodium and pleural effusion.
March 2019 in “Reactions Weekly” 12 citations
,
October 1952 in “Experimental biology and medicine” This study found that in young male rats, cortisone acetate inhibited body growth and caused alopecia, which vitamin B12 and aureomycin largely counteracted, especially when combined.
June 2020 in “Annals of the Rheumatic Diseases” This study surveyed patients with idiopathic inflammatory myopathy and found that glucocorticoid treatment commonly leads to adverse effects, particularly sleep disturbance, mood swings, and weight gain, with more severe effects reported by female patients.
12 citations
,
December 1951 in “Experimental Biology and Medicine” This study found that feeding desiccated whole liver to immature rats on a synthetic diet largely prevented the negative effects of toxic cortisone acetate doses, unlike known B vitamins.
In this study, Convulsofin was effective as monotherapy for generalized primary epilepsy and as adjunctive treatment for therapy-resistant secondary and partial epilepsy, though side effects like gastrointestinal issues and weight gain were noted.
294 citations
,
February 1994 in “PubMed” This review highlights valproic acid's efficacy and tolerability as a first-line treatment for various seizure types in both adults and children, emphasizing its minimal neurological adverse effects compared to other antiepileptic drugs.
24 citations
,
August 2009 in “Expert opinion on pharmacotherapy” This article highlights the benefits of combining calcipotriene and betamethasone for treating localized plaque-type, scalp, and nail psoriasis, enhancing effectiveness while reducing side effects compared to single-agent therapies.
2 citations
,
June 1986 in “Journal of Clinical Pharmacy and Therapeutics” This study demonstrated that certain metal salts can bind to sodium valproate and discussed the potential link to hair loss in patients treated for epilepsy.
December 2021 in “Black sea journal of health science” This case report describes a 31-year-old male who developed eosinophilic pleuropericardial effusion potentially linked to long-term valproic acid use, which resolved after adjusting his medication.
September 2022 in “Journal of Sulaimani Medical College” In this study, the combination of topical minoxidil 5% and betamethasone valerate 0.1% achieved slightly higher depigmentation in vitiligo of hair-bearing areas but did not show significant improvement over betamethasone valerate alone.
January 2004 in “Headache” This study found that two-thirds of patients with persistent chronic daily headache showed significant improvement with divalproex sodium treatment, although common side effects included weight gain, tremor, hair loss, and nausea.
January 2019 in “Egyptian Journal of Dermatology and Venereology /Egyptian Journal of Dermatology and Venerology” This study investigated the efficacy and safety of a gel combining topical calcipotriol and steroid for alopecia areata. It found the combination worked similarly to steroids alone in reducing hair loss, but with fewer side effects.
24 citations
,
November 1978 in “JAMA” This study reports that valproic acid is effective in treating absence seizures and shows improvement in other types of seizures, though about 20% of patients experienced adverse effects.
170 citations
,
June 1974 in “BMJ” This study found that sodium valproate effectively stopped or reduced seizures in patients with various types of epilepsy, with best results in absence and myoclonic seizures, though it caused temporary hair loss in some cases.
August 2018 in “Online journal of neurology and brain disorders” This study reported that sodium valproate completely stopped epilepsy in 43% of patients and reduced seizures by 50% in 22% of patients who were resistant to other anticonvulsants.